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DAILY DRUGS > PERIPHERAL VASODILATORS > Flashcards

PERIPHERAL VASODILATORS Flashcards

1
Q

Indications of pentoxiffyline

A

Intermittent claudification in peripheral vascular disease

Adjunct in venous leg ulcers

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2
Q

Dosage for pentoxiffyline

A

400mg 2 - 3 times daily

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3
Q

Mechanism of pentoxiffyline

A

A xanthine derivative which is a nonselective PDE inhibitor
improves red blood cell flexibility
reduces blood viscosity
decreases platelet aggregation
antagonist at adenosine 2 receptors

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4
Q

Contraindications of pentoxiffyline

A

Cérébral hemorrhage
Retinal hemorrhage
Severe cardiac arrhythmias
Hypersensitivity
Acute MI

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5
Q

Pentoxiffyline in lactation

A

Excreted in breast milk, do not use

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6
Q

Pentoxiffyline in pregnancy

A

Category C, use when benefits outweigh risks

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7
Q

Adverse effects of pentoxiffyline

A

Nausea and vomiting
GIT disturbances
Angina
Pancytopenia
Hypotension
Angioedema
Bronchospasm
Hemorrhage
Headache

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8
Q

When is dose adjusted for pentoxiffyline

A

Hepatic impairment

Renal impairment, eGFR<30: give 400mg once daily

Digestive or CNS side effects: Decrease to 400 mg BID

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DAILY DRUGS (11 decks)

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