Pharm

Question 1

Gq vs Gs

Answer 1

Gq –> incr Ca and PKC –> incr MLCK –> contracts SM

Gs –> incr cAMP –> decr MLCK –> relaxes SM

Question 2

Effect of prog and CRH on cAMP?

Answer 2

keep it high so SM relax

Question 3

PGE2 (Dinoprostone)/PGE1 (Misoprostol)effects on EP1 or EP2-3-4 receptors?
(prostaglandins _
ADR

Answer 3

EP1 –> Gq –> myometrial contractions
EP2-3-4 –> Gs –> cervix ripening/dilation
ADR: GI cramps, diarrhea, nausea

Question 4

PGF2a

Answer 4

FP –> Gq –> contraction

Question 5

Oxytocin & admin

Answer 5

OXT –> Gq

IV or IM, NOT oral

Question 6

EPI

Answer 6

B2 –> Gs

Question 7

Drugs for each stage of labor:

Answer 7

1. PGs for dilation and effacement
2. PGs and OXT and VSCC L type
3. hemorrhage contianed by oxytocin

Question 8

Ergot alkaloids - large dose indication?

Answer 8

to control bleeding via sustained contraction of uterus if oxytocin not working

Question 9

NSAID Indomethacin

ADR

Answer 9

Inhib, oral or IV
24-32 weeks (drops PGs)
ADR: premaure closure of ductus arteriosis - PULM HTN

Question 10

Nifedipine

Answer 10

CCB, inhib, ORAL
32-34 weeks
NOT for renal dysfxn
REFLEX TACHY or drop in BP

Question 11

Terbutaline

Answer 11

B2 agonist so, inhib
IV, oral, SC
ADR: anxiety, hypOkalemia, hypERglycemia

Question 12

Mifepristone

Answer 12

competitive progesterone receptor antagonist
abortive
if

Question 13

Oxytocin (when sensitive)

Answer 13

Uterus not sensitive until 20-36 weeks

sensitive to PGs throughout preg

Question 14

PDE5 ED drugs work how?

Answer 14

Stop breakdown of cGMP so maintain vasodilation effect

cGMP rise due to NO activity

Question 15

Most effective ED drug?

Answer 15

all equal

Question 16

ED drug DDIs?

Answer 16

a-blockers, nitrates for chest pain may cause an unsafe drop in blood pressure

Question 17

ED drugs metabolized by?

Answer 17

CYP3A4

Question 18

ED drug longest half life?

Answer 18

Tadalfil

Question 19

Sildenafil with food or on empty stomach?

Answer 19

empty stomach (also has risk of visual disturbance)

Question 20

Only indication for MgSO4?

Answer 20

Preeclampsia