pharm final Flashcards

1
Q

The volume of distribution =

A

Dose / [Plasma concentration]

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2
Q

Radiation annual limit

A

5 rem

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3
Q

Noise Pollution

A

90dB for 8hrs
MAX allowable exposure is 115dB

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4
Q

fire triad

A

fuel source
ignition
oxidizer

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5
Q

Sensitivity

A

responsiveness/reactivity

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6
Q

Selectivity

A

preference

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7
Q

Specificity

A

particular ligand over another

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8
Q

Standard Deviation

A

Quantifies the variation within a set of measurements.

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9
Q

Standard Error of the Mean

A

Quantifies the variation in the means from MULTIPLE sets of measurements.

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10
Q

first order kinetics

A

Most drugs
Constant fraction
Curve
First: Fraction, slope

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11
Q

zero order kinetics

A

Constant Amount
Phenytoin, alcohol, ASA, Heparin, Warfarin
Zero: amount, zero slope

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12
Q

Perfusion-dependent elimination

A

Drugs that have a high extraction ratio of 0.7 or greater rely heavily on the perfusion of the liver to be cleared

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13
Q

Capacity-dependent

A

elimination occurs with agents that possess a low extraction ratio of 0.3 or less

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14
Q

Elimination is how many half lives

A

4-5 half-lives 95% of the drug is eliminated from the body

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15
Q

Lipid Solubility Directly

A

potency

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16
Q

Increase Fa/Fi
wash in

A

High fresh gas flow
high alveolar concentration
Low FRC
Low time constant
low anatomic dead space

17
Q

Increase Fa/Fi
decrease uptake

A

low solubility
low CO
low Pa-Pv difference

18
Q

A decreased rate of rise of FA/FI means a

A

slower induction

19
Q

An increased rate of rise means a

A

Faster induction

No Don’t Stop It Honey

High FGF, low CO, Low Drug solubility

20
Q

blood gas coefficient

A

how fast it acts from the time its givem

21
Q

oil gas coefficient

A

how long it takes to come off

high OGC = longer lasting

22
Q

Diffusion Hypoxia

A

when you don’t give 100% FIO2 at the end of the case

23
Q

DISH how quickly the percentage of metabolism

A

Nitrous 0.004%
Desflurane 0.02
Isoflurane 0.2
Sevoflurane 2
Halothane 20

24
Q

Nitrous Oxide is 34x more soluble than what?

A

Nitrogen

25
Q
A