pharm final Flashcards
The volume of distribution =
Dose / [Plasma concentration]
Radiation annual limit
5 rem
Noise Pollution
90dB for 8hrs
MAX allowable exposure is 115dB
fire triad
fuel source
ignition
oxidizer
Sensitivity
responsiveness/reactivity
Selectivity
preference
Specificity
particular ligand over another
Standard Deviation
Quantifies the variation within a set of measurements.
Standard Error of the Mean
Quantifies the variation in the means from MULTIPLE sets of measurements.
first order kinetics
Most drugs
Constant fraction
Curve
First: Fraction, slope
zero order kinetics
Constant Amount
Phenytoin, alcohol, ASA, Heparin, Warfarin
Zero: amount, zero slope
Perfusion-dependent elimination
Drugs that have a high extraction ratio of 0.7 or greater rely heavily on the perfusion of the liver to be cleared
Capacity-dependent
elimination occurs with agents that possess a low extraction ratio of 0.3 or less
Elimination is how many half lives
4-5 half-lives 95% of the drug is eliminated from the body
Lipid Solubility Directly
potency