Pharm Quiz 4

Question 1

Temperature suppositories are designed to melt, soften, dissolve

Answer 1

31-35 degrees C or body temperature (37 degrees)

Question 2

Advantages of cocoa butter

Answer 2

Oleaginous - lipophilic suppository base

Adv: no irritating to sensitive membrane tissues, excellent emollient

Question 3

Disadvantages of cocoa butter

Answer 3

Disadvantages: poor and erratic release of some drugs, store products under refrigeration to avoid

Question 4

Advantages of PEG base and glycerinated gelatin

Answer 4

water soluble
Adv: useful for vaginal and urethral suppositories, provides more reliable release of drug, does not require carefully monitored storage temperatures

Question 5

Disadvantage of water soluble suppository bases

Answer 5

Disadvantages: irritating to body cavity and tissues

Question 6

Wecobee, Witepsol

Answer 6

Composed of synthetic triglyceride (fatty acid bases), do not have the formulation difficulties of coco butter (no polymorphism) , more expensive
Oleaginous suppository base

Question 7

Fatti base

Answer 7

Composed of a mixture of _______
Do not have the formulation difficulties of cocoa butter (no polymorphism)
Not as expensive as wecobee or witepsol
Oleaginous suppository base

Question 8

Polybase

Answer 8

Water soluble, dissolves in body fluids instead of melting at body temperatures.

Question 9

How should cocoa butter be dissolved to be compounded in an effective suppository base?

Answer 9

Melted at higher body temperatures, 31-35 degrees C

Question 10

Why should suppositories made with glycerinated gelatin should be stored in an airtight container?

Answer 10

They will absorb the atmospheric moisture otherwise, they are hydroscopic