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From Flashcardlet > pharma 4.4 Dermatologic Pharmacology > Flashcards

pharma 4.4 Dermatologic Pharmacology Flashcards

0
Q

Wet dressings

A

Moisture evaporates
Cools and dries skin
Softens dried blood and sera
Stimulates drainage

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1
Q

Tinctures

A

Contains alcohol

Water soluble

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2
Q

Creams

A

For dry scaly lesions

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3
Q

Ointments

A

For oozing lesions

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4
Q

Gels

Powders

A

For hairy areas

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5
Q

Emulsified vanishing creams

A

For intertriginous areas w/ causing maceration

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6
Q

Bacitracin+Polymixin B+Neomycin

A

Prevents minor skin injuries

Nephrotoxic

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7
Q

Gentamycin+Neomycin

A

Aminoglycoside antibiotics

Effective against G+ and G- bacteria

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8
Q

Neomycin

A

Nephrotoxic and neurotoxic

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9
Q

Antibiotic+corticosteroid

A

For diaper dermatitis/otitis externa

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10
Q

Mupirocin

Retapamulin

A

For impetigo contagiosa

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11
Q

Mupirocin

A

Inhibits isoleucyl-tRNA synthetase

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12
Q

Mupirocin

A

Bactroban (brand name)

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13
Q

Mupirocin

A

Also called pseudomonic acid A

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14
Q

Mupirocin

A

Topical antibacterial agent for most G+ aerobic bacteria and MRSA
Intramasal ointment eliminate Staph aureus in nares

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15
Q

Retapamulin

A

Semisynthetic pleromutilin derivative

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16
Q

Retapamulin

A

Impetigo for adults and greater than 9months

Uncomplicated superficial skin infection by grp A beta hemolytic strep and staph aureus excluding MRSA

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17
Q

Retapamulin

A

ADR: occasional local irritation

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18
Q

Polymyxin B sulfate

A

Peptide antibiotic

Against G- organisms and PEEK (P. aeruginosa, E. coli, Enterobacter, Klebsiella)

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19
Q

Gentamycin and neomycin

A

Aminoglycoside antibiotics for G- and PEEK
excreted renally
Avoid in renal failure
(Nephrotoxic, neurotoxic, ototoxic)

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20
Q

Neomycin

A

Frequently causes ACD

Nephrotoxic and neurotoxic

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21
Q

Gentamycin

A

More active than neomycin against P. aeruginosa and grp A beta strep

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22
Q 
Erythromycin
Clindamycin
Dapsone
Metronidazole
Sulfacetamide (lotion-wash)
Vitamin A (retinoic acid)
Benzoyl peroxide
Azelaic acid
A

8 topical antibiotics for acne

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23
Q

Vit A (Retinoic Acid)

A

Teratogenic anti acne drug

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24
Q

Benzoyl Peroxide

A

Comedolytic

Pregnant and infants

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25
Q

Azelaic acid

A

For males with severe acne

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26
Q

Azelaic acid

A

Blocks conversion of testosterone to dihydrotestosterone

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27
Q

Retinoic acid

A

DOC for acne vulgaris

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28
Q

Tazatorene

A

Acetylenic retinoid
For mild to moderately severe facial acne
CI: pregnant women

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29
Q

Benzoyl peroxide

A

Panoxyl

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30
Q

Benzoyl peroxide

A

Antimicrobial against P. Acnes and to its peeling and comedolytic effects

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31
Q

Benzoyl peroxide

A

Bleaches hair and fabrics
Carcinogenic
SAFE FOR PREGNANT WOMEN

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32
Q

Azelaic acid

A

Prevent conversion of testosterone to DHT

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33
Q

Itraconazole

A

Triazole with longest half life

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34
Q

Fluconazole

A

Triazole for Cryptococcal meningitis

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35
Q

Voriconazole

A

Triazole for Aspergillosis of lungs

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36
Q

Fluconazole
Voriconazole
Itraconazole

A

3 triazoles

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37
Q

Itraconazole

A

For multiple infection of nails

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38
Q

Rhambdomyolysis

A

Danger of Azoles with statin

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39
Q

Additive depression of respi or cardio

A

Danger of azoles with benzodiazepines

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40
Q

Arrhythmia

A

Danger of azoles with CV drugs

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41
Q

Miconazole

Ketoconazole

A

Vaginal cream or suppository for vulvovaginal candidiasis

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42
Q

Ketoconazole

A

Nizoral

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43
Q

Clotrimazole

A

Canesten

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44
Q

Ketoconazole

A

Shampoo for seborrheic dermatitis

45
Q

Ketoconazole

A

ADR:
Male gynecomastia
Irregular menstruation

46
Q

Terbinafine

A

Onchomycosis

47
Q

Acyclovir

A

Precursor of valacyclovir
Oral
For herpes simplex genitalis and herpes encephalitis

48
Q

Penciclovir

A

Precursor is famciclovir
Oral
For herpes simplex labialis

49
Q

Doconasol

A

For herpes simplex labialis

50
Q

Trifluridine

A

Opthalmic

51
Q

Trifluridine

A

For herpes keratitis

52
Q

Topical antiviral agents

A

Inhibits DNA polymerase, oligoribonuclease, thymidine kinase

ADR:
Pruritus and mild pain with transient stinging or burning with acyclovir and penciclovir

53
Q

Penciclovir

A

For recurrent orolabial herpes simplex virus infection in immunocompetent adults

54
Q

Imiquimod

A

Immunomodulators/suppressants with ADR: flu like symptoms

55
Q

Tacrolimus

A

Immunomodulator or suppressant for atopic dermatitis

Do not use with occlusive dressings

56
Q

Malathion

A

For pediculosis only

An organophosphate poison (irreversible anti-ACE)

57
Q

Sulphur

A

All ectoparasiticides are CImfor prenant women except ?

58
Q

Trioxsalen

A

For vitiligo
With UVA
Oral
ADR: melanoma and cataract formation

59
Q

Methoxsalen

A

For psoriasis

60
Q

Acitretin

A

For pustular forms of psoriasis
Retinoic acid derivative
ADR: HYPERVITAMINOSIS
CI: Pregnancy

61
Q

Calcipotriene/calcitriol

A

SAFE FOR PREGNANCY
vit D3
For PLAQUE psoriasis
ADR: hypercalcemia

62
Q

Etanercept

A

SQ
Psoriatic arthritis
Combined with methotrexate

63
Q

Infliximab

A

IV

Chimeric IgG1 monoclonal antibody

64
Q

Adalimumab

A

SQ

Recombinant IgG1 monoclonal antibody

65
Q

Ustekinumab

A

New drug

Anti IL22/IL23 inhibitng T helper cell 1 to 17

66
Q

Acitretin

A

More teratogenic than isotretinoin

67
Q

Calcipotriene

A

DOC for psoriasis in pregnant women

For plaque type psoriasis vulgaris of moderate severity

68
Q

Bethametasone

A

Lung maturation in premature infant

69
Q

Betamethasone
Clobetasol
Halobetasol

A

Highest efficacy in topical corticosteroids

70
Q

Methylprednisone/dexamethasone

A

Lowest efficacy among topical corticosteroids

71
Q

Propylene Glycol

A

Humectant

ADR: ACD

72
Q

Podophyllum/podofilox

A

Inhibits thymidylate synthetase

73
Q

Urea

A

BEST AND SAFEST KERATOLYTIC

74
Q

5-FU

A

For Actinic keratoses

75
Q

Doxepin

A

For atopic dermatitis

An antidepressant TCA

76
Q

Pramoxine

A

Local anesthetic
For eczematous dermatitis
Prevents hypersecretion of keratin by blocking intracellelular sodium channels

77
Q

Salicylic acid

A

DOC for severe toxicity is HEMODIALYSIS

78
Q

Propylene glycol

A

ADR:

Allergic contact dermatitis

79
Q

Urea

A

MOA:

Alterations in prekeratin and keratin leads to inc solubilization

80
Q

Urea

A

Safest keratolytic

Best humectant

81
Q

Podophyllum resin

A 
For condyloma acuminatum
MOA:
Active cytotoxic agent
Epidermal mitoses arrested in metaphase
CI: pregnancy
82
Q

Podofilox

A

Pure podophyllotoxin
For genital condylomas
ADR: local inflamm, erosion, burning pain, itching

83
Q

Fluorouracil 5-FU

A

DOC for multiple actinic keratoses

MOA: inhibits thymidylate synthetase activity

84
Q

Aminolevulinic acid (ALA)

A

Endogenous precursor of photosensitizing porphyrin metabolites
MOA: formation of cytotoxic superoxide and hydroxyl radicals

Avoid exposure to sunlight or bright indoor lights for 40hrs after application

85
Q

Doxepin

A

Treatment for pruritus assoc woth atopic dermatitis or lichen simplex chronicus

CI: untreated narrow-angle glaucoma or tendency to urinary retention

86
Q

Eflornithine

A

Anti trichogenic

87
Q

Minoxidil

A

Vertex balding is more responsive than frontal balding

Cessation of Tx lead to hair loss in 4-6mos

88
Q

Minoxidil

A

Androgenic alopecia

89
Q

Finasteride

A

May cause hypospadia on male fetus, teratogenic

90
Q

Eflornithine

A

Hair returns in 8weeks when stopped
DOC for African Sleeping Sickness
MOA irreversible inhibitor of ornithine decarboxylase

91
Q

Alitretinoin

A

AIDS-related kaposi sarcoma

92
Q

Antimetabolites

A

Psoriasis, pemphigus

93
Q

Chlorhexidine

A

Antiseptic wash (oral/vaginal)

94
Q

Thalidomide

A

Erythema nodosum leprosum

95
Q

Antimetabolites
Corticosteroids
Dapsone
Methotrexate

A

May cause pemphigus

96
Q

Antihistamines H1

A

Pruritus, urticaria

97
Q

Antimalarials

A

Lupus erythematosus

Photosensitization

98
Q

Becaplermin

A

Diabetic neuropathic ulcers

99
Q

Bexarotene

A

Cutaneous T cell lymphoma

100
Q

Corticosteroids

A

Pemphigus, pemphigoid, lupus erythematosus, allergic contact, dermatitis, SLE

101
Q

Cyclosporine

A

Psoriasis

102
Q

Dapsone

A

Dermatitis herpetiformis
Erythema elevatum diutinum
Pemphigus, pemphigoid, bullous lupus erythematosus

103
Q

Denileukin diftitox

A

Cutaneous T cell lymphoma

104
Q

Drospirenone

Ethinyl estradiol

A

Moderate female acne

105
Q

H-chlorquine

A

Lupus erythematosus

Photosensitization

106
Q

Interferon a

A

Melanoma

Viral warts

107
Q

Mycophenolate mofetil

A

Bullous dse

108
Q

Vorinostat

Romidepsin

A

Histone-deactylase

109
Q

Bimatoprost

A

ADR: Eyelash extension
For glaucoma Tx
PGF2A antagonist

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