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Pharma Flashcards

Pharma

1
Q

Drug resistant gonorrhea

A

Spectinomycin

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2
Q

Toxicity of aminoglycoside

A

Nephrotoxicity reversible

Ototoxicity irreversible

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3
Q

Most ototoxic aminoglycoside

A

Kanamycin

Amikacin

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4
Q

Resistance of gentamycin

A

Plasmid mediated

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5
Q

AG with narrowest therapeutic window

A

AMIKACIN

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6
Q

Most nephrotoxic Ag

A

Tobra genta

Acute tubular necrosis

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7
Q

Neuro mucular blockade of Aminogly

A

Curare like

Tx: Calcium nd neostygmine

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8
Q

Aztreonam coverage

A

Klebsiella
Pseudomonas
Serratia

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9
Q

Aztreonam coverage

A

Klebsiella
Pseudomonas
Serratia

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10
Q

MOA OF CHLORAMPHENICOL

A

Inhibit TRANSPEPTIDATION at 50s subunit

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11
Q

Resistance of tetracycline

A

Efflux pump

Formation of ribosomal protection

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12
Q

Silver sulfadiazine Side effect

A

Hypersensitivity
Acute hemolysis in g6pd
Hematotoxic
Kernicterus

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13
Q

DOC for toxoplasmosis

A

Sulfadiazine pyrimethamine

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14
Q

Fluoroquinolone

1st generation spectrum

A

UTI

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15
Q

2nd gen fluoroquionolone spectrum

A

Gram neg
gonococci
Gram pos
Mycoplasma

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16
Q

2nd gen fluoroquionolone spectrum

A

Gram neg
gonococci
Gram pos
Mycoplasma

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17
Q

3rd gen fluoroquionolone spectrum

A

Less gram neg
More gram pos
Strep, entero

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18
Q

4th gen fluoroquionolone spectrum

A

Broad with anaerobes

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19
Q

Isoniazid MOA

A

Inhibit mycolic acid synthesis

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20
Q

Most important anti TB drug

A

Isoniazid

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21
Q

Resistance of isoniazid

A

Deletion of KatG gene

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22
Q

Side effect isoniazid

A

Hepa
Neuro
Acute hemo on g6pd
Drug induced lupus

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23
Q

MOA rifampicin

A

Inhibit Dna dependent Rna polymerase

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24
Q

Light chain protenuria

A

Rifampicin

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25
Q

Anti Tb na CYP450 inhibitor

A

Isoniazix

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26
Q

Anti TB cyp450 inducer

A

Rifampicin

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27
Q

Used for travelers diarrhea

A

Rifamixin

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28
Q

Rifam for HIV

A

Rifabutin

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29
Q

Anti TB

Flu like symptom

A

Rifampicin

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30
Q

Anti TB asymptomatic hyperuricemia

A

PZA

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31
Q

Sterilizing agent

A

PZA

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32
Q

Most hepatotoxic anti TB

A

PZA

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33
Q

Resistamce of PZA

A

Mutation of Pnca gene

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34
Q

MOA OF DAPSONE

A

Inhibit folic acid synthesis

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35
Q

Clofazimine Moa

A

Binds to guanine bases

Leprosy drug

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36
Q

Prophylazix for atypical mycobac

A

Clarith or azith

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37
Q

Atypical mycobac drug

A

Azit or claritj with rifabutin and etham

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38
Q

Side effect of amphothericin

Infusion reaction

A

Chills fever muscle spasm hypotension

39
Q

Flucytosine MOa

A

Thru permease ans deaminase

Converted to 5fu then inhibit thymidilate synthase

40
Q

Flucytosin SE

A

Myelosupp, alopecia, heoatox

41
Q

Ketokonazole MOA

A

Inihibit p450 dep enzymes blocking ergosterol synthesis

42
Q

Antifungal with good CNS permeability

A

Fluconazole

43
Q

Salvage therapy for invasive aspergillosis

A

Caspofungin

44
Q

Inhibit b glucan synthase

A

Caspofungin

45
Q

Anti viral binds to gp41 sub unit

A

Enfuvirtide

46
Q

Anti viral ccr5 antagonist

A

Maraviroc

47
Q

Activated by thymidine kinase inhibit dna polymerase

A

Acyclovir

48
Q

Prevent uncoating by bindibg to m2 proton channel

A

Amantadine

For influenza A

49
Q

Inhibit neuraminidase for influenza

A

Oseltamivir

50
Q

BZD used as date rape drug

A

Flunitarezam

long acting

51
Q

Chelation for mercury

A

Succimer and unithol

52
Q

Loose gums and teeth Gi disturbances neuro behavioral change

A

Mercury poisoning

53
Q

Gray cyanosis GI bleeding

A

Iron

54
Q

Tx chronic arsenic poisoning

A

Dimercaprol

55
Q

Gi discomfort rice watery stool

Burning of coal

A

Acute

Arsenic

56
Q

Gi discomfort rice watery stool

Burning of coal

A

Acute

Arsenic

57
Q

Hair loss transverse band mee’s line

Milkn and roses complexion

A

Arsenic poisoning

58
Q

Idustrial exposure
Abdominal colic, acutr enceph

Poison? Tx?

A

Lead

Succimer and
Edta plus dimercaprol

59
Q

Idustrial exposure
Abdominal colic, acutr enceph

Poison? Tx?

A

Lead

Succimer and
Edta plus dimercaprol

60
Q

Shortest acting barbiturate

A

Thiopental

61
Q

Shortest acting barbiturate

A

Thiopental

62
Q

BZD as anticonvulsant maintenance and bipolar disorder

A

Clonazepam

63
Q

Status epilepticus

A

Diazepam, lorazepam

64
Q

BZD for insomnia

A

Estazolam

65
Q

Panic disorder BZD

A

Alprazolam

66
Q

BARBITURATE THAT INC INC GLUCORONYL TRANSFERASE BINDING

A

Phenobarbital

67
Q

BLOOD ALCOHOL LEVEL CAUSING COMA

A

300-400 mg/dl

68
Q

Blood alcohol level causing resp depression

A

More than 500

69
Q

Blood alcohol level causing driving impairment

A

60 to 80

70
Q

DOC for generalized tonic clonic seizure

A

Phenytoin

71
Q

DOC for partial seizure

A

Phenytoin

72
Q

Watersoluble prodrug of phenytoin

A

Fosphenytoin

73
Q

DOC for Trigem neuralgia

A

Carbamazepine

74
Q

Teratogen of carbamazepine

A

Spina bifidaa and craniofacial

75
Q

Side effect oxcarbazepine

A

HyponTremia

76
Q

Given at initiation therapy for valproic acid

A

BZD

77
Q

Primary anti convulsant for infabts children and pregnant

A

Phenobarb

78
Q

DOC for absence seixure

A

Ethosuximide

79
Q

Causes sjs anti seizure

A

Carbamazepine

Lamotrigene

80
Q

Anti seizure which can precipitate psychosis or schiz

A

Levitiracetam

81
Q

Anti seizure

Hepatic failure ITP aplastic anemia

A

Felbamate

82
Q

Generalized tonic clonic

A

PVC
Phenytoin
Valproic
Carbamazepine

83
Q

PARTIAL seizure

A

CPL
Carbamazepine
Phenytoin
Lamotrigine

84
Q

Absence seizure

A

EV
Ethosuximide
Valproic acid

85
Q

Myoclonic and atypical absence

A

Valproic

86
Q

Status epilepticus

A 
PHEN PHEN LanDi
Phenobarb
Phenytoin
Diaz
Loraz
87
Q

Local anesth for ophta

A

Tetracaine

Proparacaine

88
Q

Local anesh causing methemog

A

Prilocaine

89
Q

Longest halflife among local anesth

A

Ropivacaine

90
Q

Nondepolarizing muscle relaxant

Fastest onset

A

Rocuronium

91
Q

Antidote for tubocurarine

A

Neostigmine

92
Q

Non dep muscle relaxant causing seizure

A

Atracurium

93
Q

Strychinne poisoning

A

Pancuronium

94
Q

Gambling and hypersexuality among antipsych

A

Pramipexole

Pharma (1 decks)

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