Pharmacokinetics

Question 1

The dosing interval can also be described as the ____

Answer 1

Frequency

Question 2

Describe the Pharmacodynamics relationship

Answer 2

Concentration Vs Effect

Question 3

Describe the Pharmacokinetics relationship

Answer 3

Dose vs Time vs Concentration

Question 4

Name some types of parenteral routes of administration

Answer 4

aural (AU, AD, AS)
ophthalmic (OU, OD, OS)
nasal
inhaled
intravenous (IV)
intramuscular (IM)
intradermal (ID)
subcutaneous (SC or SQ)
intrathecal
intraosseous
intra-arterial
intravaginal
topical

Question 5

Clinically “enteral” means what?

Answer 5

oral

Question 6

Clinically “parenteral” usually refers to what?

Answer 6

injections

Question 7

What type of drugs can leave the bloodstream (or be active)

Answer 7

“unbound” or “free” drugs

Question 8

What is total clearance defined as?

Answer 8

Renal + Hepatic + Other (Lung, sweat, breast milk etc)

Question 9

In a healthy patient, what is the normal GFR?

Answer 9

120 ml/min

Question 10

What type of medication/dose does this PK curve represent?

Answer 10

IV Bolus/ IV Push

Question 11

What type of medication/dose does this PK curve represent?

Answer 11

Daily oral doses

Question 12

What type of medication/dose does this PK curve represent?

Answer 12

Single oral dose

Question 13

What type of medication/dose does this PK curve represent?

Answer 13

Continuous Infusion

Question 14

This is an example of a drug with a long or short drug interval? Why?

Answer 14

Long, Drug is dosed at long intervals relative to the t1/2 so the drug levels will have large fluctuations between Cmin and Cmax

Question 15

This is an example of a drug with a long or short drug interval? Why?

Answer 15

Short, drug is dosed at short intervals relative to the t1/2 so the drug levels will have smalled fluctuations between Cmin and Cmax