Pharmacokinetics Formulas & Theories Flashcards
1
Q
Concentration = ?
A
Conc = Dose/Vd
2
Q
Rate of Infusion formula
A
Ri = Css x Cl total
3
Q
Bioavailability Formula
A
Dose x F = Bioavailability
F = bioavailability factor
4
Q
Css = ____ = _____
A
Css = Ri/Ke x Vd = Ri/CLtotal
5
Q
Cl total = ?
A
Cl total = Ke x Vd
6
Q
T1/2 = ?
A
T1/2 = (0.693)Vd/Cl
Vd = must be in Liters!
(Liters/kg may be used in the question)
Cl must be in L/hour
7
Q
Maintenance Dose Formula
A
MD = Cl x Css/F
Css = steady state concentration
F = bioavavilability factor
Cl = clearance (in L/min)
8
Q
Bioavailability Factor
A
F = Amt. bioavailable/Amt. given
9
Q
A
10
Q
F is what?
A
Bioavailability factor
11
Q
Loading Dose Formula
A
Loading Dose = Plasma concentration x Volume of distribution/Bioavailability Factor
LD = Conc x Vd/f
12
Q
Vd =
A
Vd = D/Cp
