pharmacokinetics of elimination

Question 1

formula for clearance

Answer 1

clearanve= volume of distribution* Ke

Question 2

what is Ke

Answer 2

fraction of drug eliminated per unit time

Question 3

Clearance formula

Answer 3

Clearance= (maintenance dose/tau)/Cp(Steady state)

Question 4

what is tau

Answer 4

interval between doses

Question 5

total elimination is how many half lives

Answer 5

4-5

Question 6

tim eto steady state with constant administration

Answer 6

4-5 half lives

Question 7

degree of fluctionation between doses

Answer 7

2^x where x= # of half lives in T

Question 8

t (1/2)=?

Answer 8

0.693/Ke

Question 9

elimination rate constant (ke) definition

Answer 9

refraction of drug leaving the body per unit time via all elimination processes

Question 10

first order elimination means that

Answer 10

a constant fraction of drug is being eliminated per time independent of total drug present

Question 11

zero order kinetics of elimination means that

Answer 11

constant amount eliminated/unit time not constant rate

Question 12

volume of distribution is indirectly proportional to

Answer 12

amount of drug in plasma

Question 13

4 things that cause a decrease in bioavailiablity

Answer 13

first pass metabolism in the liver, drug degradation in stomach/gut, poor solubility, poor absorption