Pharmacology

Question 1

Dose of high dose Ara-C

Answer 1

3 g/m2

Question 2

Side effect of Ara-C

Answer 2

Cerebellar toxicity

Question 3

Bilirubin threshold for doxorubicin.

Answer 3

Contraindicated with bili > 5.

Question 4

Trade name for lenalidomide.

Answer 4

Revlimid

Question 5

Trade name for pomalidomide.

Answer 5

Pomalyst.

Question 6

Trade name for bortezomib.

Answer 6

Velcade.

Question 7

Drug that targets IDH1 mutation.

Answer 7

Ivosidenib

Question 8

Drug that targets IDH2 mutation.

Answer 8

Enasidenib.

Question 9

What drug can be used as maintenance for FLT3 AML after alloSCT?

Answer 9

Sorafenib.

Question 10

Plerixafor mechanism of action

Answer 10

CXCR4 antagonist, helps with stem cell mobilization.

Question 11

What BCMA-BiTE requires what consultation prior to starting?

Answer 11

Balantamab Mafodotin; ophtho due to keratopathy

Question 12

Drug may be used in multiple myeloma with t(11;14)

Answer 12

Venetoclax

Question 13

Mutations in CXCR4 predict lack of response to what drug in Waldenstrom Macroglobulinemia?

Answer 13

BTK inhibitors

Question 14

Target of brentuximab

Answer 14

anti-CD30 ADC

Question 15

Mechanism of action of obinutuzumab (used in poor performance status CLL)

Answer 15

anti-CD20 monoclonal antibody

Question 16

Main side effect of ibrutinib (treats mantle cell, CLL/SLL, waldenstroms, marginal zone).

Answer 16

A fib

Question 17

Main side effect of acalabrutinib.

Answer 17

Myelosuppression.

Question 18

Main side effect of bortezomib.

Answer 18

Viral infections
Need viral PPx with valacyclovir.
Neuropathy.

Question 19

Votinostat, Romidepsin mechanism of action.

Answer 19

Histone deacetylase (HDAC) inhibitors)