Pharmacology

Question 1

what is pharmacokinectics

Answer 1

what the body does to the drug- absorption, secretion, distribution and metabolism

Question 2

what is pharmacodynamics

Answer 2

what the drug does to the body- biological effects and mechanism of action

Question 3

define what a drug is

Answer 3

any single synthetic or natural substance of known structure that is used in the treatment, prevention or diagnosis of disease

Question 4

how do drugs act

Answer 4

by binding to specific target molecules

Question 5

list the six targets drugs can bind to

Answer 5

(regulatory proteins);
enzymes 
carrier molecules (transporters and pumps)
ion channels 
receptors 
RNA
DNA

Question 6

what is an agonist

Answer 6

a drug that binds to a receptor to produce a cellular response

Question 7

what is an antagonist

Answer 7

a drug that blocks the action of the agonist by binding to the same receptor

Question 8

what is a ligand

Answer 8

a molecule that binds to another molecule

Question 9

define affinity

Answer 9

the strength of association between a ligand and receptor

Question 10

define efficacy

Answer 10

the ability of an agonist to provoke a cellular response

Question 11

define potency

Answer 11

measure of drug intensity- amount required to produce an effect of given intensity

Question 12

define competitive inhibition

Answer 12

binding of agonist and antagonist occur at same orthosteric and thus are competitive and mutually exclusive

Question 13

define non competitive inhibition

Answer 13

agonist binds at orthosteric site and antagonist binds at separate allosteric site and is thus non competitive

Question 14

receptors are mostly what

Answer 14

protein macro molecules

Question 15

what is EC50

Answer 15

the concentration or dose of an agonist that elicits a half maximal response