pharmacology of the airways

Question 1

what are the 2 zones of the airways called

Answer 1

conducting and respiratory

Question 2

which post-ganglionic parasympathetic nerve fibres cause bronchoconstriction
what receptor

Answer 2

cholinergic M3

Question 3

which post-ganglionic nerve fibres cause bronchodilation
what receptor

Answer 3

NANC, NO receptor

Question 4

what are the Ach related bronchodilator medicine

Answer 4

M3 antagonists (SAMA and LAMA) eg iprotropium(SAMA) glycopyrronium(LAMA)

Question 5

what is the first line of treatment for asthma

Answer 5

ICS

BROWN!!!!!! beclometasone

Question 6

how does ICS work

Answer 6

interfering with HAT and HDAC
pro-inflammatory genes switched off
anti-inflam genes switched on

Question 7

what is 1st line treatment for COPD

Answer 7

LABA or LAMA

Question 8

give some examples of pro-inflam mediators

Answer 8

IL6 CLCX-8

Question 9

which IG meidates allergy

Answer 9

IgE

Question 10

what happens when Ig pathway is set into action with allergy

Answer 10

mast cell degranulation