PHYSIO-RENAL Flashcards
renal waste product from proteins
urea
renal waste pruduct from purines
Uric Acid
ranal waste product from the muscle
Creatinine
renal waste product from rbc’s
Bilirubin
examples of hormone metabolites of kidneys
VMA,Metanephrine
formed in the interstitial cells of the periocapillariesof the kidneys which increases RBC pruduction in cases of hypoxia
EPO
a hormone secreted by the kidneys which is an active form of Vit.D
Calcirtiol
glucose is not usually seen in urine, but normal in pregnancy due tosaturation of glucose receptors?.t or f
TRUE
kidneys are located in T? to L?
T12 - L3
why is R kidney lower than the left
because of the liver size
which part of the kidney is stretched when pus accumulates giving you a (+)KPT in pyelonephritis
Capsule
struvite composed of AMP(ammonium,magnesium,phosphate) Stone produced by Proteus mirabilis seen as radio opaque
Staghorn Calculi
trace the renal circulation
renal artery - segmental artery - interlobar artery - arcuate artery - interlobular artery(aka cortical radiate/radial artery) - afferent arteriole - glomerular capillaries - efferent arteriole - peritubular capillaries/vasa recta - interlubular vein - arcuate vein - interlobar vein - renal vein
only capillaries in human body that leads to arterioles and not venules, responsible for GFR
Glomerular capillaries
the interstitial cells inperitubular capillaries secretes what?
EPO
hairpin loop-shaped peritubular capillaries of he juxtamedullary nephrons that participate in countercurrent exchange
VASA RECTA
capacity of the Urinary Bladder
600ml
urge to urinate is how much
150ml (25%)
reflex contraction of the urinary bladder is how much
300ml (50%)
bladder muscle is your?
Detrusor Muscle (stimulation of B2 for Relaxation)
Internal Urethral Sphincter is Voluntary or Involutary
INVOLUNTARY
External Urethral Sphincter is Voluntary or Involuntary
Voluntary
functional and structural unit of the kidney
Nephron
how many nephrons does a normal human being has approx.
2 million (1M each)
Nephron are capable of Regeneration? T or F
FALSE
kidneys undergo compensatory hypertrophy upon 75% damge of nephrons?t or f
TRUE
what is the % of your Cortical Nephrons? Juxtamedullary Nephrons?
Cortical=75% ; Juxta=25%
location of cortical and juxta nephrons?
Cortical Nephrons=RENAL CORTEX; Juxtamedullary Neph=CORTICO-MEDULLARY JUNCTION
LOOPS OF HENLE of Cortical and Juxta Neph?
cortical neph=Short loop ; juxtamed neph=Long loop of henle
capillary network of cortical and juxta neph
cortical neph=PERITUBULAR CAPILLARIES Justamed neph=VASA RECTA
part of the nephron where you find your bowman’s space and bowman’s capsule aka Malphigian Corpuscle
renal corpuscle
Nephrotic Syndrome’s “EPAL”
edema,proteinuria,albuminemia,lipedemia
Nephritic Syndrome’s “Oh Ha”
oliguria, hematuria, HTN, azotemia
1st cahrged barrier of the RenalCorpuscle which is 50x more permeable than skeletal muscle capillaries and secete NO & Endothelium-1
Capillary Endothelium
last charged barrier of the Renal Corpuscle which are cells of the capillary endothelium containing foot processes and filtration slits
Podocytes
found in between Tufts of capillaries involved in glomerular diseases
Mesangial Cells
aka “glomerular cells of the afferent arterioles” secretes RENIN (ayun benta anf renin)
JG cells
found in the walls of the Distal Convoluted Tubule which monitors Na concentration in the DT(and consecuently Blood Pressure)
Macula Densa
Na-K-2Cl pump is found in which Loop of Henle inhibited by loop diuretics
Thick Ascending Limb Loop of Henle
Thiazide acts on Loop of Henle or Distal Tubule or Collecting Duct
Distal Tubule
ADH acts on Loop of Henle or Distal Tubule or Collecting Duct
Collecting Duct
amount filtered in the glomerular capillaries per unit time GFR
125ml/min or 180L/day
normalfriction fraction is howmany %
20%
how many angstromis filtered freely (according to size)
20 angstrom or less
how many angstrom is not filtered at all
> 40 angstrom