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Flashcards in Physiology 2 Deck (18):
1

The thin descending loop of Henle is impermeable to _______, and thus reabsorbs _______.

sodium, water

2

The thin descending Loop of Henle absorbs water b/c of medullary _______.

hypertonicity

3

The thick ascending loop of Henle is impermeable to _______, and thus reabsorbs _______.

water; Na+, K+, and Cl- (directly) and Mg++ and Ca++ indirectly.

4

What kind of transport brings Na+, K+, and Cl- into the epithelial cells of the ascending loop of Henle from the tubular lumen?

Active cotransport

5

How do Mg++ and Ca++ get reabsorbed from the lumen of the ascending Loop of Henle?

They diffuse in between the cells due to a positive charge (+7 mV) inside the lumen.

6

What are the effects of PTH on tubular reabsorption? (2 segments)

Blocks Na+/phosphate cotransport @ PCT.
Increases Na+/Ca++ exchange @ DCT.

7

There is a renal tubular transporter on which Thiazide diuretics and Ang II have opposite effects. What is it and where is it located?

Na+/Cl- cotransporter in the DCT

8

Site of action of furosemide.

Na+/K+/Cl- cotransporter in the TAL

9

Aldosterone and potassium-sparing diuretics have opposite actions on the same channel. What channel is this and where is it located?

Na+ channel (ENaC) in the principal cells of the collecting tubule

10

What are the (2) aldosterne antagonist K+-sparing diuretics?

Spironolactone and eplerenone

11

What are the ENaC inhibiting K+-sparing diuretics?

Amiloride and Triamterene

12

How does ADH work?

Causes the insertion of aquaporins into the luminal membrane of collecting tubule epithelial cells.

13

What percentage of Na+ is reabsorbed at the PCT?

65-80%

14

What percentage of Na+ is reabsorbed at the TDL

0%

15

What percentage of Na+ is reabsorbed at the TAL?

10-20%

16

What percentage of Na+ is reabsorbedat the DCT?

5-10%

17

What percentage of Na+ is reabsorbed at the collecting ducts?

3-5%

18

What is a posible side effect of thiazide diuretics?

Hypercalcemia