Pituitary and Hypothalamic Glands

Question 1

What is the most common mutation in pituitary adenomas?

Answer 1

G protein mutations

Question 2

Gnas mutations common in GH adenomas but is absent in what types of pituitary adenomas?

Answer 2

Gonadotroph, Lactotroph and Thyrotroph adenomas

Question 3

Which of the following is more common of lactotroph adenomas?
A. Chromophobic, sparsely granulated, PIT1 juxtanuclear
B. Chromophobic, densely granulated, diffuse cytoplasmic PIT1
C. Acidophilic, sparsely granulated, PIT1 juxtanuclear
D. Acidophilic, densely granulated, PIT1 diffuse cytoplasmic

Answer 3

A. Chromophobic, sparsely granulated, PIT1 juxtanuclear

“CSJ”

Question 4

What is the most common hyperfunctioning pituitary adenoma?

Answer 4

Lactotroph adenoma

Question 5

What is the second most common hyperfunctioning pituitary adenoma?

Answer 5

GH- secreting somatotroph adenoma

Question 6

Corticotroph adenoma are most commonly? 
A. Acidophilic, sparsely granulated 
B. Acidophilic, densely granulated
C. Basophilic, sparsely granulated
D. Basophilic, densely granulated

Answer 6

D.

Question 7

What are the most common hormones secreted by pituitary carcinoma?

Answer 7

Prolactin and ACTH

Question 8

What are the two distinctive histologic feature of putuitary adenoma?

Answer 8

Monomorphism and lack of reticulin network

Question 9

The following statements are true regarding craniopharyngioma, except.
A. Bimodal age distribution
B. Adamantinomatous variant is most often observed in children
C. Papillary variant lack keratin, calcification and cysts
D. Papillary variant is negative for Beta catenin

Answer 9

D.
Remarks: adamantinomatous - nuclear and membranous staining of beta catenin.
Papillary variant - membranous staining of beta catenin. Braf staining.