Postnecrotic Cirrhosis

Question 1

Definition and aetiology

Answer 1

~ Post hepatics cirrhosis/ macronodular cirrhosis/ coarsely nodular cirrhosis

Aetiology :
~ Viral hepatitis: B and C
~ drugs: phosphorus, CCl4, mushroom, Alfa methyl dopa, acetaminophen
~ infections: Brucellosis, Clonorchis, Wilson’s disease, ALD
~ idiopathic

Question 2

Morphology

Answer 2

Gross: liver is small, irregular, macronodules of varying sizes + broadband fibre
Micro :
~ loss of architecture
~ macronodules : >3mm
~ fibrosis
~ inflammation

Question 3

Clinical Features

Answer 3

~ females more common
~ cirrhosis features
~Splenomegaly , hypersplenism
~HCC later