Practice 1-4

Question 1

5% of liver cells are ____

Answer 1

Polyploids

Question 2

Polyploids cells are also called

Answer 2

POlythene giant cells

Question 3

Giant cells derived by

Answer 3

Endomitosis

Question 4

What is the result of not having cytokinesis?

Answer 4

Multinucleated giant cell

Question 5

In which Meiosis Nondisjunction we have 50% of producing healthy cells?

Answer 5

Meiosis II

Question 6

Nondisjunction=

Answer 6

Failure of homologous chromosomes or sister chromatids to separate properly during cell division

Question 7

What is essential in meiosis? (3)

Answer 7

Two divisions
Chr. number is halfed
Genetic variability

Question 8

Meiosis I Prophase consists of

Answer 8

Leptotene
Zygotene
Pachytene
Diplotene
Diakinesis

Question 9

Which phase is the lomgest in Prophase I?

Answer 9

Pachytene

Question 10

In which phase does crossing over occurs?

Answer 10

Pachytene

Question 11

When is the chiasma visible?

Answer 11

Diplotene

Question 12

When does synaptonema complex forms?

Answer 12

Zygotene

Question 13

In which prophase phase does chromosomes condense?

Answer 13

Leptotene

Question 14

Where can we find PAR1/2

Answer 14

On the telomer region of both X and Y chr.

Question 15

Chiazma=

Answer 15

Site of creossing over

Question 16

What is the cause of aneuploid genom mutation?

Answer 16

Meiotic nondisjunction

Question 17

Meiotic nondisjunction is more frquent in

Answer 17

Oogenesis

Question 18

p=q is called

Answer 18

Metacentric

Question 19

Whic chr. has NOR?

Answer 19

Acrocentric

13,14,15,21,22

Question 20

Which region are dark in G-banding

Answer 20

A-T

Question 21

FISH=

Answer 21

Fluorescent In Situ Hybridization

Question 22

What number of SCE is not normal?

Answer 22

14-200

Question 23

What is the most common trisomy leading to unviable offspring (miscarriage)

Answer 23

16

Question 24

47,XXY=

Answer 24

Klinefelter syndrome

Question 25

47,XY+13=

Answer 25

Patau syndrome

Question 26

47,XY+18=

Answer 26

Edwards syndrome

Question 27

45,X=

Answer 27

Turner syndrome

Question 28

Genetic disorder due to chromosome terminal deletion on chromosome 5

Answer 28

Cri du Chat

Question 29

Philadelphia chr. is an example of

Answer 29

Reciprocal translocation

Question 30

Example for non-Mendelian

Answer 30

Mitochondrial

Question 31

AD inheritance examples

Answer 31

Osteofenesis imperfecta
Achondroplasia
Huntington chorea
Marfan syndrome
Familial hypercholeterolemia

Question 32

AR inheritance examples

Answer 32

PKU
Albinism
Cystic fibrosis
Sickle cell anemia
Thalassaemia

Question 33

X linked Dominant inheritance.

Affected male aith normal women have affected son?

Answer 33

No

Question 34

X linked Dominant inheritance examples

Answer 34

Hypophosphatemia
Fragile X
Amelogenesis imperfecta

Question 35

X-linked recessive.

Who is more affected?

Answer 35

Male

Question 36

X linked Recessive inheritance examples

Answer 36

Duchenne musclular dystrophy
Becker musclular dystrophy
Hemophilia A,B
Red-green colour blindness

Question 37

SRY=

Answer 37

Testis-determining factor (TDF), also known as Sex-determining Region Y

Question 38

Mitochondrial inheritance example

Answer 38

Leber’s optic atrophy

Question 39

GIve an example of age dependent penetrance

Answer 39

Huntington’s disease

Question 40

Variable expressivity

Answer 40

Degree in which a genotype is phenotypically expressed

Question 41

Penetrance=

Answer 41

Proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype)

Question 42

Phenocopy=

Answer 42

Variation in phenotype which is caused by environmental conditions