Practice Test Review!

Question 1

What abbreviations can you not use at UCH

Answer 1

ad, aid, qod, as, al, ad, au, os, ol, od, ou

Question 2

which requires FDA evaluation: health claims or structural/function claims

Answer 2

health claims

Question 3

3 things that determine drug category

Answer 3

medical use, abuse potential, potential for dependency

Question 4

what does a drug in category 2 require

Answer 4

a doc to write in ink the script, cannot phone in

Question 5

most common means of absorption

Answer 5

lipid diffusion passive

Question 6

four factors that affect drug membrane passage

Answer 6

molecular size, lipid solubility, degree of ionization, concentration gradient

Question 7

what means of administration fall into the following categories of bioavailability: 100, 75-100, 0-100

Answer 7

100- IV, 75-100: IM, subQ, sublingual, inhalation, transdermal, 0-100 is oral

Question 8

how long does IV and inhalation take to effect

Answer 8

seconds to minutes- FASTEST

Question 9

how long does sublingual, IM, subQ, and buccal take to take effect

Answer 9

5-15 minutes- intermediate

Question 10

immediate release oral formulation- time to effect?

Answer 10

15-30 minutes

Question 11

time to effect for transdermal, oral (enteric coated or sustained release drugs) and IM and SC (if depot forms)

Answer 11

HOURS- slowest

Question 12

Formula for Loading dose

Answer 12

Cp(desired)*Vd

Question 13

when pH<pKa, which is ionized (acids or bases?)

Answer 13

bases are ionized

Question 14

when pH> pKa, which is ionized?

Answer 14

acids are ionized

Question 15

4 areas of tight junctions where drugs have to pass THROUGH cells

Answer 15

GI, BBB, placenta, renal tubules (for REabsorption)

Question 16

Volume of plasma/blood and what it means for that drug

Answer 16

3-5 L, drugs are highly bound to plasma proteins

Question 17

volume of extracellular water and what it means for that drug

Answer 17

12-15 L, drugs are water soluble and don’t enter cells

Question 18

volume of total body water and what it means for that drug

Answer 18

42 L,d rugs that freely enter cells

Question 19

other compartments of body volume and what it means for that drug

Answer 19

> 50, highly lipid soluble and get sequestered at tissue sites

Question 20

3 reactions that happen with phase 1

Answer 20

oxidations reductions and hydrolysis

Question 21

fluoxetine and cimetidine effect on CYP450

Answer 21

inhibit

Question 22

low extraction drugs- do they have good or bad hepatic metabolism

Answer 22

poorly metabolized by the liver

Question 23

high lipid water coefficient means its excreted (quickly or slowly?)

Answer 23

slowly- hangs in cells and tissues

Question 24

glomerulus filtration rate

Answer 24

120 mL/min

Question 25

RZBF

Answer 25

600 mL/min

Question 26

passive reabsoption int he kidneys depends on what

Answer 26

pH

Question 27

active secretion (reabsorption) in the kidneys rate

Answer 27

120-600 mL/mi

Question 28

time to reach steady state

Answer 28

4-5 half lives* time of each half life

Question 29

degree of fluctuations in plasma between doses equation

Answer 29

time between doses/time of each half life

Question 30

time to reach steady state is dependent on ____ and independent of ____

Answer 30

half life, drug dosage

Question 31

elimination kinetics equation:

Answer 31

Ln(C2/C1)=(-ke)*t

Question 32

fold fluctuation equation

Answer 32

2^x where x= number of half lives in the dosing interval

Question 33

to determine Vd on a graph look at:

Answer 33

Cp at time zero and do amount of drug in the body/concentration of drug in plasma

Question 34

CYP2A4-5

Answer 34

most drug metabolism

Question 35

CYP2D6

Answer 35

metabolizes codeine into morphine

Question 36

CYP2C9

Answer 36

metabolizes warfarin

Question 37

CYP2C10

Answer 37

Asians have lots of polymorphisms

Question 38

CYP2E1

Answer 38

metabolizes acetometophin in phase 1 reactions– hepatotoxicity