PSA

Question 1

Phenytoin, carbamazepine, rifampicin and baribiturates are enzyme inducers or inhibitors ?

Answer 1

enzyme inducers

Question 2

Chronic excess of alcohol and sulfonylureas act as inhibitors or inducers ?

Answer 2

inducers

Question 3

Allopurinol, omeprazole, disulfiram, erythromycin, valrpoate, isoniazid, ciprofloxacin, ethanol ( acute intoxiciation ) and sulphonamides: these drugs are inducers or inhbitors ?

Answer 3

inhibitors

Question 4

what is pharmacodynamics ?

Answer 4

effects of drugs on the body

Question 5

what does pharmacokinetics mean ?

Answer 5

what does the body do to the drug: absorption, metabolism, excretion

Question 6

What happens if long term corticosteroids for example prednisolone is stopped during surgery ?

Answer 6

profound hypotension, since patients have adrenal atrophy, thus unable to mount an adequate stress response to surgery. Thus IV steroids should be given during surgery

Question 7

What are the steroids sick day rules ?

Answer 7

double the daily dose to counter the increased steroid requirement when ill

Question 8

Which drugs need to be stopped before surgery ?

Answer 8

insulin, lithium, anticoagulants, antiplatelets, COC, HRT, K-sparing diuretics, oral hypoglycaemics, perindopril and other ACE inhibitors

Question 9

How long before surgery should HRT/COC be stopped ?

Answer 9

4 weeks

Question 10

How long before surgery should lithium be stopped ?

Answer 10

day before

Question 11

How long before surgery should potassium sparing diuretics and ACE inhibitors be stopped ?

Answer 11

day of surgery