Psych Flashcards
structural abnormalities in schizophrenia
overactive limbic-positive symptoms
underactive frontal-negative symptoms
enlargement of lateral ventricles due to cell death and developmental failure
positive symptoms of schizophrenia
hallucinations
delusions
catatonia
agitation
negative symptoms of schizophrenia
flattened affect apathy social withdrawal anhedonia poverty of thought poverty of speech
delusions of persecution
others are trying to harm, spy on, interfere with affairs of patient
delusions of reference
random events have special meaning to patient
delusions of influence
belief patient’s thoughts are controlled by outside sources
thought broadcasting
patient’s thoughts are being sent directly to an outside source
grandiose delusions
patients belief they are elevated in importance; more common in psychotic mania
somatic delusions
belief the body has been manipulated in some way; device inserted, body controlled by others
typical treatment for ECT
8-14 treatments
2-3x/week under general anesthesia
electrode placement for ECT
bitemporal
right unilateral
bilateral electrode placement
electrodes midline
used for patients who require faster response or who fail RUL
right unilateral electrode placement
one electrode lateral to vertex and other at right temple
administered 6x patient seizure threshold
muscle relaxants in ECT
succinylcholine
non-depolarizing (atracurium, rocuronium)
variations in succinylcholine metabolism
severe hepatic disease nutritional deficiencies pseudocholinesterase deficiency (prolong apnea)
anesthetics used in ECT
methohexital-superior due to low cardiac toxicity
etomidate-adrenal insufficiency decreases use
ketamine-used when maximum stimulus reached without adequate seizure response to barbituates
indications for ECT
major depressive disorder-MDD with psychotic features
bipolar disorder-rapid cycling, delirious mania
thought disorder-schizophrenia and schizoaffective
NMS
Parkinson disease
ECT not effective for
anxiety disorders personality disorders substance-use disorders autism spectrum disorders persistent depressive disorder
contraindications for ECT
no absolute contraindications relative contraindications -recent intracranial hemorrhage -recent thromboembolic stroke -intracranial lesion causing mass effect -recent MI -unstable angina or decompensating heart failure -unstable vertebral fracture
adverse cognitive effects of ECT
postictal disorientation
interictal confusion
memory impairment-anterograde or retrograde amnesia (usually resolved by 6 months)
resolving amnesia in ECT
anterograde resolves more quickly
retrograde takes longer-months
other adverse effects of ECT
cardiovascular-dysrhythmias, ischemia
headache, nausea, muscle soreness, dental problems
mood switch to mania or mixed state
treatment of mood switch from ECT
mood stabilizer
continuing ECT treatment
results of ECT
release of monoamine NT (dopamine and serotonin)
desensitizing presynaptic adrenergic autoreceptors
decreased metabolic activity in frontal and cingulate cortex
BDNF induces neurogenesis and sprouting from granule cells in hippocampus
treatment with light therapy
seasonal affective disorder
timing of light therapy
30 min/day
position 1-2 feet away (don’t stare at it)
max 90/day (increase to 45 min 1-2x)
indications for light therapy
not actively suicidal
history of favorable response to light therapy
no history of poor outcome with light therapy
somatization disorder
recurring multiple physical complaints before 30 leading to impairment in social, occupational areas
not intentionally produced
>6 months
pain symtpoms in somatization disorder
2 GI
1 sexual
1 pseudo neuro
prevalence of somatization disorder
1%
10:1 F:M
genetic link-alcoholism, antisocial PD
increased incidence with parental divorce, poverty and alcoholism
treatment of somatization disorder
supportive with regular appointment
treat comorbid psychiatric disorders
conversion disorder
1 or more symptoms affecting voluntary motor or sensory symptoms
motor, sensory, convulsions, and mixed presentation
treatment of conversion disorder
psychotherapy
treat comorbid psychiatric condition
rule out medical condition
support of diagnosis of conversion disorder
stress
not feigned
lack of concern
hypochondriasis
reoccupied with fears of serious illness
misinterpretation of bodily symptoms
not delusional intensity
epidemiology of hypochondriasis
common in both gender
raised in family with excessive concern about illness
treatment of hypochondriasis
avoid unnecessary tests
sympathetic and educational approach is ideal
factitious disorder
falsification of physical or psychological sign and symptom or induction of injury or illness associated with identified deception
motivation-assumption of sick role
external incentives are absent
malingering disorder
intentional production of false or grossly exaggerated symptoms for external incentives
marked discrepancy in presentation, lack of cooperation
presence of antisocial personality disorder
definition of intellectual disability
reduced level of intellectual functioning resulting in diminished ability to adapt to the daily demands of the normal social environment
epidemiology of intellectual disability
mild intellectual more common in lower socioeconomic
more severe is evenly distributed
diagnosis of intellectual disability
subnormal intellectual functioning (below 70)
adaptive deficits
onset during the developmental period
borderline intellectual disability IQ
70-79
mild intellectual disability IQ
55-70
moderate intellectual disability IQ
35-50
severe intellectual disability IQ
20-35
profound intellectual disability IQ
<20
adaptive deficits
failure to develop age appropriate skills communication self care social and interpersonal skills health work safety
onset of intellectual disability
during developmental period
before age 18
genetic disorders associated with intellectual disabilities
Downs syndrome
Prader Willi
Fragile X
characteristics of Downs syndrome
many do not live past 40
often placid and adaptive in childhood
neural plaques and neurofibrillary tangles
characteristics of Prader Willi
compulsive eating behavior, obesity
hypogonadism, small stature, small hands and feet
often oppositional-defiant
characteristics of Fragile X
high rates of ADHD and autism
rapid perseverative speech
most common inherited, 2nd most common genetic after down syndrome
more common in males
PKU
inability to convert phenylalanine to paratyrosine because of absence of phenylalanine hydroxylase
diet improves behavior and developmental progress
maternal infections that cause intellectual disorders
rubella HIV cytomegalovirus toxoplasmosis herpes simplex syphilis
fetal alcohol syndrome
most common preventable cause
perinatal causes of intellectual disability
infection-meningitis or encephalitis
trauma
cerebral hypoxia
postnatal causes of intellectual disability
infection-meningitis or encephalitis
toxins-lead poisoning
characteristics of mild intellectual disability
55-69
may be able to hold a job, learn to read and write
may function independently but need assistance with social or economic stress
language slower but functional development
learn at about 6th grade level
characteristics of moderate intellectual disability
35-50
learn basic self care, simple language, function with some independence in a supported and sheltered environment
some impairment in self care
depend and function best in structured and supervised setting
severe and profound intellectual disability
will usually require institutional care limited or no language motor impairments more clearly showing CNS damage/maldevelopment restricted mobility and incontinence likely to have a clear biological cause may benefit from habit training
psychiatric disorders in the intellectually disabled
higher incidence
mood disorders, schizophrenia, conduct disorder, autism, ADHD
disruptive and conduct disorder more common in mild mental disability
autistic self stim and injury more common in moderate to severe
treatment of intellectual disability
supportive and optimized environment
behavior therapy
medications for depression, behavior dyscontrol, psychosis, and other comorbid pathology
changes to autism spectrum disorder in DSM5
Retts no longer
now autism spectrum disorder
diagnostic criteria for autism spectrum disorder
impairment in reciprocal social interaction
impairments in communication and imaginative activity
markedly restricted range of activities and interests
common social interaction difficulties for ASD
lack of social response
lack of eye contact
lack of interest in and response to affection
lack of response to emotion in others
common language abnormalities in ASD
delayed development, sometimes mute stereotyped and repetitive expression abnormal inflections and intonations abnormal use of pronouns echolalia
restricted activities and interests in ASD
anxiously obsessive insistence on sameness narrow range of spontaneous activities limited food tolerances preference for inanimate objects stereotyped and repetitive mood behavior
sensory impairments in ASD
evidence of tactile defensiveness-hate denim, don’t like tags
super hearing
epidemiology of ASD
4:1 M:F
Retts almost exclusively in female
intellect in ASD
IQ scores above 70 may be as high as 50%
visuospatial abilities and rote learning skills may be better maintained on IQ than verbal, sequencing, and abstraction skills
level 1 ASD characteristics
require support awkward social overtures may have difficulty with back and forth conversations difficulty switching between activities problems with organization Aspergers
level 2 ASD characteristics
requiring substantial support
marked problems with verbal and non-verbal communication
very limited, narrow interests
inflexibility in behavior
distress when need to change focus or action
level 3 ASD characteristics
requiring very substantial support
severe communication deficits
minimal response to social overtures
inflexibility of behaviors interfere significantly with all daily functions