Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Psychiatry > Flashcards

Psychiatry Flashcards

1
Q

Methylphenidate (MOA)

A

CNS stimulant. Increases catecholamines at the synaptic cleft, especially norepi and dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Methylphenidate (CU)

A

ADHD, narcolepsy, appetite control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dextroamphetamine (MOA)

A

CNS stimulant. increases catecholamines at the synaptic cleft, especially norepi and dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Dextroamphetamine (CU)

A

ADHD, narcolepsy, appetite control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Methamphetamine (MOA)

A

CNS stimulant. increases catecholamines at the synaptic cleft, especially norepi and dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Methamphetamine (CU)

A

ADHD, narcolepsy, appetite control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Phentermine (MOA)

A

CNS stimulant. increases catecholamines at the synaptic cleft, especially norepi and dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Phentermine (CU)

A

ADHD, narcolepsy, appetite control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Haloperidol

A

Typical antipsychotic (neuroleptic). Block dopamine D2 receptors -> Increase cAMP. High potency.
Schizophrenia (primarily positive symptoms), psychosis, acute mania, Tourette syndrome.
(T) Neurologic side effects. EPS symptoms. Neuroleptic malignant syndrome (NMS). Tardive dyskinesia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Antipsychotics (neuroleptics) (T)

A

Highly lipid soluble and stored in body fat; thus very slow to be removed from body.
Extrapyramidal system effects (dyskinesias). treatment = benztropine or diphenhydramine
Endocrine side effects (dopamine receptor antagonism-> hyperprolactin-> galactorrhea)
Side effects from blocking muscarinic (dry mouth, constipation), a1 (hypotension), and histamine (sedation) receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Neuroleptic malignant syndrome (NMS)

A

Rigidity, myoglobinuria, autonomic instability, hyperpyrexia. Treatment: dantrolene, D2 agonists (bromocriptine).
Toxicity associated with neuroleptic antipsychotics
Seen with haloperidol.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tardive Dyskinesia

A

Stereotypic oral-facial movements as a result of long-term antipsychotic use. Potentially irreversible.
Toxicity associated with neuroleptic antipsychotics
Seen with haloperidol.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Trifluoperazine

A

Typical antipsychotic (neuroleptic). Block dopamine D2 receptors -> Increase cAMP. High potency.
Schizophrenia (primarily positive symptoms), psychosis, acute mania, Tourette syndrome.
Neurologic side effects (EPS symptoms)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fluphenazine

A

Typical antipsychotic (neuroleptic). Block dopamine D2 receptors -> Increase cAMP. High potency.
Schizophrenia (primarily positive symptoms), psychosis, acute mania, Tourette syndrome.
Neurologic side effects (EPS symptoms)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Thioridazine

A

Typical antipsychotic (neuroleptic). Block dopamine D2 receptors -> Increase cAMP. Low potency.
Schizophrenia (primarily positive symptoms), psychosis, acute mania, Tourette syndrome.
Non-neuro side effects (anticholinergic, antihistaminic, and a1 blockade effects). Retinal deposits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Chlorpromazine

A

Typical antipsychotic (neuroleptic). Block dopamine D2 receptors -> Increase cAMP. Low potency.
Schizophrenia (primarily positive symptoms), psychosis, acute mania, Tourette syndrome.
Non-neuro side effects (anticholinergic, antihistaminic, and a1 blockade effects). Corneal deposits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

For NMS think FEVER

A 
Fever
Encephalopathy 
Vitals unstable 
Enzymes elevated
Rigidity of muscles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Olanzapine (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Olanzapine (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Olanzapine (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.
Weight gain.

21
Q

Clozapine (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

22
Q

Clozapine (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

23
Q

Clozapine (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.
Weight gain. Agranulocytosis (requires weekly WBC monitoring) and seizure.

24
Q

Quetiapine (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

25
Q

Quetiapine (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

26
Q

Quetiapine (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.

27
Q

Risperidone (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

28
Q

Risperidone (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

29
Q

Risperidone (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.
May increase prolactin (lactation and gynecomastia) -> decreased GnRH, LH and FSH (causing irregular menses and fertility issues)

30
Q

Aripiprazole (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

31
Q

Aripiprazole (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

32
Q

Aripiprazole (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.

33
Q

Ziprasidone (MOA)

A

Atypical antipsychotic. Varied effect on 5-HT2, dopamine, and a- and H1-receptors.

34
Q

Ziprasidone (CU)

A

Schizophrenia - both positive and negative symptoms. Also used for bipolar disorder, OCD, anxiety disorder, depression, mania, Tourette syndrome.

35
Q

Ziprasidone (T)

A

Fewer extrapyramidal and anticholinergic side effects than traditional antipsychotics.
May prolong the QT interval.

36
Q

Lithium (MOA)

A

Not established; possibly related to inhibition of phosphoinositol cascade.

37
Q

Lithium (CU)

A

Mood stabilizer for bipolar disorders; blocks relapse and acute manic events. Also SIADH.

38
Q

Lithium (T)

A 
LMNOP: 
Lithium 
Movement (tremor)
Nephrogenic diabetes insipidus 
hypOthyroidism 
Pregnancy problems
39
Q

Buspirone (MOA)

A

Stimulates 5-HT1A receptors

40
Q

Buspirone (CU)

A

Generalized anxiety disorder. Does not cause sedation, addiction, or tolerance. Takes 1-2 weeks to take effect. Does not interact with alcohol (vs. barbiturates, benzos)
“I am always anxious if the bus will be on time so I take buspirone”

41
Q

Bupropion (MOA)

A

Increases norepi and dopamine via unknown mechanism.

42
Q

Bupropion (CU)

A

Atypical antidepressant. Smoking cessation.

43
Q

Bupropion (T)

A

stimulant effects (tachycardia, insomnia), HA, seizure in bulimia patients. No sexual side effects.

44
Q

Mirtazapine (MOA)

A

alpha2-antagonist (increase release of norepi and 5-HT) and potent 5-HT2 and 5-HT3 receptor antagonists.

45
Q

Mirtazapine (CU)

A

Atypical antidepressant

46
Q

Mirtazapine (T)

A

sedation (which may be desirable in depressed pts with insomnia), increased appetite, weight gain (desirable in elderly anorexic pts), dry mouth

47
Q

Trazadone (MOA)

A

Primarily blocks 5-HT2 and alpha 1 adrenergic receptors.

48
Q

Trazadone (CU)

A

Primarily for insomnia. Atypical antidepressant: high doses needed for antidepressant effects.

49
Q

Trazadone (T)

A

sedation, nausea, pariapism, postural hypotension

Pharmacology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions