Quinolones

Question 1

MOA

Quinolones

Answer 1

DNA gyrase (topoisomerase II) and topoisomerase IV
Bactericidal
PAE

Question 2

Biovailability of Quinolones. oral or iv?

Answer 2

oral just as good

Question 3

Adverse effects

Quinolones

Answer 3

photosensitivity
QT prolongation
CNS - mental status change
Arthropathy (

Question 4

Drug interactions

Quinolones

Answer 4

Theophylline
Antacids/Iron/Sucralfate/Multivitamins
Warfarin

main effect with ciproflaxin

Question 5

Which Quinolone has better Staph/Strep coverage?

which includes excellent PCN resistant strep pneumo

Answer 5

Levofloxacin

Gemi, Moxi

Question 6

Which quinolone has SPACE coverage?

Answer 6

Cipro and Levo

Question 7

which quinolone has SACE (no pseudomonas) coverage?

Answer 7

Moxifloxacin

Gemifloxacin

Question 8

Which quinolone also has both anaerobic and atypicals coverage?

Answer 8

Moxi

levo and cipro cover only atypicals = CML

Question 9

What is the bioavailability of Cipro?

What does it provide an excellent coverage for?

Answer 9

excellent. use oral form if possible

Gram negatives

Question 10

What should Moxifloxacin NOT be used for? why?

Answer 10

UTIs - poor urinary conc

Question 11

Mechanism of resistance

Quinolones

Answer 11

altered DNA gyrase
altered drug permeability due to changes in porin channels – results in efflux of drug from bacterial cell – reduced conc intracellularly