Quiz 2

Question 1

Skin disorder characterized by disrupted skin barrier and immune hyperactivity. Skin is dry, itchy, inflamed

Answer 1

Atopic Dermatitis

Question 2

Deficiency in AD

Answer 2

Filaggrin (essential protein in epidermal barrier)

Question 3

Buildup of pro-FLG causes

Answer 3

lipids to decrease

Question 4

Lack of post-FLG metabolites leads to

Answer 4

increased pH, decreased osmolarity

Question 5

pH increases leads to serine protease excess which also is bc of

Answer 5

antigens and genetics

Question 6

Topicals for AD

Answer 6

Lipid replacement, Eucalyptus extract

Question 7

Oral therapies for AD

Answer 7

Glucosylceramide

Question 8

Systemic pathophys of AD

Answer 8

Decreased IL-10, Th2 shift,

Question 9

Nutritional therapies for AD

Answer 9

elimination diet, eliminate histamine, sodium restriction, trans fat restriction

Question 10

Fatty acid supplementation in AD

Answer 10

Flaxseed and fish oils are reasonable starting points
Flaxseed oil 10-30 ml/day
Combined EPA + DHA 1-6 g/day

Question 11

Supplements for AD

Answer 11

probiotics, glutamine

Question 12

Furunculosis is caused by

Answer 12

s. aureus

Question 13

Lesions furunculosis are

Answer 13

painful and scarring

Question 14

Nutritional strategies for furunculosis

Answer 14

restricted carb diet, anti-inflammatory diet, vit. C, raw wheat?

Question 15

Inflammation of skin causing erythema and telangiectasia

Answer 15

Rosacea

Question 16

Nutrition for Rosacea

Answer 16

Zinc, Lipase, elimination diet (hot, spicy, alcohol)

Question 17

Most common skin dz

Answer 17

acne

Question 18

Pathophysiology of acne

Answer 18

excess sebum production and decreased drainage- hormones (androgens). Bacterial (p. acnes).

Question 19

Transcription factor acting as a downregulator

Answer 19

FOXO1

Question 20

Upregulator in acne

Answer 20

mTORC-1 (increased by insulin)

Question 21

Nutrition for acne

Answer 21

Low glycemic, no milk

Question 22

Supplements for acne

Answer 22

cur cumin, EGCG topically, zinc (sometimes with Cu), Vit. A

Question 23

Psoriasis

Answer 23

Chronic, autoimmune inflammatory dermatosis

Question 24

Rx for RA

Answer 24

elimination diet, Vit. A (> 15,000 IU time dosage), Vit. D, ECGC, Alpha lipoid acid, n-3 fatty acids, olive oil, GLA, anti-inflammatory diet, brassica veggies, garlic, cur cumin, boswelia, nightshade avoidance

Question 25

PsA

Answer 25

Inflammatory polyarthritity in pts. with psoriasis

Question 26

What inflammatory markers dominate in PsA?

Answer 26

Th17 over-population

IL-23, IL-22, IL-17, IL-6 predominate

Question 27

AS genetics

Answer 27

HLA-B27 positive

Question 28

AS begins at

Answer 28

SI joints

Question 29

Extra-articular manifestations of AS

Answer 29

renal disease, iritis, cardiopulmonary complaints

Question 30

Nutritional txt of AS

Answer 30

Ongoing Th17-driven autoimmunity
Sodium restriction, vitamin A, EGCG
Intestinal hyper-permeability
Elimination diet, curcumin, antimicrobial Tx
Glutamine 8-20g/day
Reduced permeability
Reduction in childhood allergy
Unmanaged diet
Respectful, assertive dietary rehabilitation
Psychological/emotional stress
Social support, awareness practice, counseling, botanical/pharmacotherapy