Rate limiting enzymes of metabolic processes Flashcards Preview

STEP1 2014 > Rate limiting enzymes of metabolic processes > Flashcards

Flashcards in Rate limiting enzymes of metabolic processes Deck (15):
1

glycolysis

phosphofructokinase 1
enhanced by AMP, fructose-2,6-bisphosphate
inhibited by ATP, citrate

2

gluconeogenesis

fructose-1,6-bisphosphate
enhanced by ATP, Acetyl CoA

3

TCA cycle

isocitrate dehydrogenase

enhanced by ATP
inhibited by AMP, fructose-2,6-bisphosphate

4

Glycogenesis

glycogen synthase

enhanced by glucose-6-phosphate, insulin, cortisol
inhibited by epinephrine, glucagon

5

Glycogenolysis

glycogen phosphorylase

enhanced by epinephrine, glucagon, AMP
inhibited by glucose-6-phosphate, insulin, ATP

6

HMP shunt

glucose- 6- phosphate dehydrogenase (G6PD)

enhanced by NADP
inhibited by NADPH

7

De novo pyrimidine synthesis

Carbamoyl phosphate synthetase II

8

De novo purine synthesis

Glutamine- phosphoribosylpyrophosphate (PRPP) amidotransferase
inhibited by AMP, inosine monophosphate (IMP), GMP

9

urea cycle

carbamoyl phosphate synthetase I
enhanced by N- acetylglutamate

10

fatty acid synthesis

acetyl- coA carboxylase (ACC)

enhanced by insulin, citrate
inhibited by glucagon, palmotoyl- CoA

11

fatty acid oxidation

carnitine acyltransferase I
inhibited by malonyl CoA

12

Ketogenesis

HMG CoA Synthase

13

Cholesterol synthesis

HMG CoA reductase

enhanced by insulin, thyroxine
inhibited by glucagon, cholesterol

14

bile acid synthesis

7-alpha-hydroxylase

15

heme synthesis

aminolevulinate synthase