Receptors/Ligands

Question 1

T cell receptor LFA-1 (integrin)

Answer 1

ICAM-1, ICAM-2 (immunoglobulin) Integrin activation increases a T cell’s affinity for the ligand allowing adhesion

Question 2

T cell receptor CD2 (immunoglobulin)

Answer 2

LFA-3 T cell adhesion and signaling

Question 3

T cell receptor L-selectin

Answer 3

GlyCAM-1 (sulfated sialyl-Lewis) T cell adhesion to endothelial cells

Question 4

T cell receptor CD28

Answer 4

B7-1, B7-2 Second T cell signal after TCR-MHC Class II binding

Question 5

T cell receptor CTLA-4

Answer 5

B7-1, B7-2 CTLA-4 is only expressed on activated T cells and binding sends an inhibitory signal

Question 6

T cell receptor (TCR)

Answer 6

MHC + peptide First antigen recognition signal to activate T cell

Question 7

T cell receptor CD40 ligand (CD40-L)

Answer 7

CD40 on B cells Expression of CD40-L is induced by T cell activation. Binding induces activation of B cells.

Question 8

T cell receptor VLA-4

Answer 8

VCAM-1 on endothelial cells Adhesion to endothelium