Reproductive Endo - Lecture 4 Flashcards
primary male hormone
testosterone (T)
testosterone is an
androgen
which is more potent? DHEA or Testosterone?
Testosterone
5a-reductase
converts testosterone to DHT (most potent androgen)
why is it necessary for GnRH stimulation to be pulsatile?
necessary for gonadotropin secretion. Continuous, nonpulsatile GnRH release downregulates GnRH receptors and inhibits FSH/LH secretion
Estradiol (E2) feedback
positive feedback actions on LH secretion prior to ovulation
gonadal steroid feedback
mostly negative feedback control of GnRH and LH secretion
activation of steroid receptors regulates
gene transcription
gene transcription in gonads regulates:
gametogenesis and hormone synthesis
gonadal steroid regulate
protein synthesis in reproductive organs - breasts, uterus, male accessory glands, brain