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Pharm 2 > Reproductive Pharm > Flashcards

Reproductive Pharm Flashcards

1
Q

Mifepriston

A

Progestin Antagonist

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2
Q

Ulipristal

A

SPRM w/in 120hr

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3
Q

Plan B

A

Estrogen+Progestin w/ 72hr

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4
Q

Exogenous testosterone Benefits

A

hypogonadism, skeletal growth w/ pituitary dwarfism, infertility, ED, muscle tone and strength, Bone marrow stimulation for anemia, osteoporosis, transgender patient

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5
Q

Exogenous testosterone Risks

A

Increased risk of liver dz such as hepatitis and HCC, Acne, decreased sperm, prostatic hyperplasia, increase LDL

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6
Q

What form of exogenous testosterone is ineffective?

A

Oral, it bypasses 1st metabolism

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7
Q

What are the CI of Exogenous testosterone

A

cancer, bph, liver dz, hyperlipidemia

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8
Q

What does exogenous testosterone cause in children

A

Abnormal sexual maturation, decreased height, increased agression

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9
Q

What class is Leuprolide

A

Anti-androgenic + antiestrogenic. It is an analog of GnRH to interrupt testosterone +estrogen

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10
Q

What is the indication of Leuprolide

A

Prostate CA, endometriosis, uterine fibroids. It is

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11
Q

What is Finasteride

A

5 Alpha-Reductase Inhibitor to limit the conversion of testosterone to DHT

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12
Q

What are the important things to know about a patient with finasteride

A

They can not donate blood and women who want to become pregnant should not take it

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13
Q

Why give finasteride

A

BPH and Male Pattern Baldness

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14
Q

What is Tamsolusin

A

Alpha-1-Adrenergic Receptor Blocker

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15
Q

What are the injectable agents to treat diabetes

A

Pramlintide, Exenatide, Insulin

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16
Q

Which injectable agent treats both type I and Type 2 diabetes

A

Pramlintide

17
Q

What is Pramlintide

A

Injectable Agent for Diabetes I & II: It is a synthetic amylin that allows for less insulin use. Cant be combined int he same syringe as insulin

18
Q

What is Exenatide

A

Injectable Agent for Diabetes II. Incretin mimetic from Glia Monster

19
Q

Can you use insulin orally

A

No it is a protein so the stomach acid breaks it down

20
Q

What is the main side effect of insulin use

A

Hypokalemia

21
Q

Rapid Acting Insulin

A

Lispro + Hymulong
Onset: 15 min
Peaks: 30-90
Lasts: 3-5 hr

22
Q

Short Acting Insulin

A

Regular Hummulin R
Onset: 30 min
Peaks: 2-4 hours
Lasts: 4-12 hours

23
Q

Intermediate Acting Insulin

A

NHP (Hummulin N)
Onset: 1-3 hr
Peaks: 6-12 hr
Lasts: 24-48 hr

24
Q

Long Acting Insulin

A

Glargine (Lantus)
Onset: 4-6 hr
NO PEAK
Lasts: 24 hr

give this for coverage during sleep

25
Q

What drugs are sulfonylureas

A

Chlorpropamide, tolbutamide, glipizide, glyburide and glimepiride

26
Q

How do sulfonylureas work and what are their risks

A

Stimulate beta cell to release insulin

risks: renal/liver impairment, hypoglycemia, weight gain

27
Q

What drugs are biguanides

A

Metformin

28
Q

How do biguanides work and what are their risks

A

improve insulin sensitivity in skeletal muscle and decrease hepatic glucose production

Risk of Lactic acidosis and renal insufficiency

Does NOT cause hypoglycemia

29
Q

What drugs are meglitinides

A

Nateglinide and repaglinide

30
Q

How do meglitinides work?

A

stimulate beta cell to release insulin

31
Q

What Drugs are glitazones

A

Rosiglitazone, pioglitazone and troglitazone

32
Q

What are the risks and how do glitazones work

A

improve insulin sensitivity in skeletal muscle and decrease hepatic glucose production

risk:CHF, MI, Bone density loss, Increase bone fracture

33
Q

What drus are alpha-glucosidase inhibitors

A

Acarbose and miglitol

34
Q

How do alpha-glucosidase inhibitors work

A

inhibit alpha glucosidase in brushborder of small intestine to interfere with hydrolysis of CHO

Risk: rare fatal hepatic failure

35
Q

which diabete drug can cause acute pancreatitis

A

Sitagliptin

Pharm 2 (1 decks)

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