Respiratory Flashcards

1
Q

what is the Guidelines for treatment of community acquired pneumonia

A

Amoxicillin 1 gm three times a day - best evidence

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2
Q

If pt can not take amoxicillin for CAP what should they take

A

Doxy or a macrolide (azithromycin, clarithromycin)

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3
Q

is an acute infection of the lung in a patient who acquired the infection in the community, not an inpatient or residential facility.

A

CAP

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4
Q

most common cause of CAP pneumonia is

A

Mycoplasma Pneumonia

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5
Q

Second most common cause of penumonia is

A

Strep pneumonia

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6
Q

The most common etiologic agent in pneumonia worldwide is

A

Steptococcus Pneumoniiae

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7
Q

Clinical evaluation of a patient with suspected pneumonia always begins with

A

clinical examination and chest X-ray.

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8
Q

what is the gold standard of diagnosis of Pneumonia

A

presence of an infiltrate

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9
Q

device that measures the amount of air you breathe in and out.

A

spirometry

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10
Q

what age needs to be hospitalized for CAP

A

under 3 months

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11
Q

measures maximum speed of expiration.

A

peak expiratory flow rate

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12
Q

Most commonly viral infection that causes inflammation of the bronchial tubes= mucous production inside causing narrowing of airways.

A

acute bronchitis

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13
Q

Presentation of acute bronchitis

A

Sudden onset of dry or productive (light colored sputum) paroxysm cough that keeps person up at night, may have low grade fever, mild wheezing, may have chest pain. Can last 4-6 weeks. Objective findings: lungs clear to severe wheezing, percussion is resonant, CXR benign.

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14
Q

acute bronchtitis tx is

A

Symptomatic management: ↑fluids, ↑rest, stop smoking, antitussives, expectorant, albuterol for wheezing.

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15
Q

Reversible airway obstruction caused by chronic inflammation of the bronchial tree.

A

asthma

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16
Q

w/inspiration, systolic BP drops due to ↑ pressure.

A

pulsus paradoxus

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17
Q

Loss of elastic recoil of the lungs and alveolar damage that takes decades, results in hyperinflation of the lungs.

A

Emphysema

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18
Q

Presentation of emphysema

A

Weight loss, barrel chested, pursed-lip breathing, hx heavy smoker, SOB on exertion, chronic productive cough, large amounts of light-yellow sputum.
* Percussion with hyperresonance, decreased tactile fremitus and egophony.
CXR: flattened diaphragms with hyperinflation.

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19
Q

An acute infection in which bacteria attach to the cilia of respiratory epithelial cells, causing inflammation that inhibits clearance of secretions. In an effort to clear secretions, affected patients exhibit violent bursts of coughing with a characteristic “whooping” sound.

A

pertusis

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20
Q

Pertussis has three stages:

A

tage 1: Catarrhal (1-2 weeks)
Insidious onset of nonspecific upper respiratory symptoms: nasal congestion, rhinorrhea, sneezing, and mild cough
Malaise, conjunctival suffusion, lacrimation, low-grade or no fever
Stage 2: Paroxysmal (2-8 weeks, up to 10 weeks)
Coughing spells increase in severity in the first 2 weeks and become violent, frequent, and spasmodic. The coughing spells can remain intense for up to a month before gradually lessening. Episodes of coughing may last several minutes
Cough may be more prominent at night
Posttussive vomiting is common and a sensitive and specific finding for pertussis
Stage 3: Convalescent (8-12 weeks)
Cough subsides and disappears over weeks to months
The characteristic cough can return up to several months later if another upper respiratory infection is acquired

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21
Q

leukocytosis (15,000-50,000/mL) with absolute lymphocytosis occurs during what in pertussis

A

late stage of one and two

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22
Q

what is the gold standard lab study for pertussis

A

Nasopharyngeal culture - best if within first 2 weeks of cough onset

23
Q

what other lab test can you do for pertussis is a

A

PCR to detect DNA sequence of Bordetella pertussis (primary test used)

24
Q

Isolation of patient or caretakers exposed to pertussis should occur until

A

antibiotic therapy has been adminstered for 5 days, or three wees after cough onset if no Abx

25
Q

Consider hospitalization for (pertussis)

A

infants younger than 6 months, infants who were born preterm, and patients with comorbidities that increase health risks

26
Q

what is the treatment choice for pertussis for abx

A

macrolides (Azythro, Erythro, Clarithro).
Azithromycin is the drug of choice for pertussis; it has a dual role for treatment and for postexposure prophylaxis.

27
Q

Tdap boosters at what age

A

11 - 18

28
Q

how long does it take for pertussis to get to recovery

A

2-3 months

29
Q

TB skin test (Mantoux Test)

A

Equal to or >5 mm = recent contact , HIV + immunocompromised
>10 mm = immigrants, IV drug useers, health care workers, community setting (jail, NH)
> 15 mm = no TB risk

30
Q

Gold standard for Dx is

A

sputum for culture

31
Q

what is the initial testing

A

Interferon gamma-release assays (IGRA); indeterminate or borderline IGRA results are often due to lab error and should be repeated

32
Q

IF Tb test is positive what should u order

A

chest x ray
If chest X-ray negative and no signs of active disease, diagnose latent TB
If chest X-ray positive, look for airway opacities, cavities, pleural effusions

33
Q

TB shows on x ray in

A

upper lobes cavitation/granulomas

34
Q

TX for TB is

A

INH + rifampin + ethambutol + pyrazinamide

35
Q

CURB 65 is

A

C: confusion
U: blood urea nitrogen >19.6mg/dL R: respirations >30 breaths/min
B: BP <90/60
65: = or > 65 years old.

36
Q

First line treatment for CAP

A

No comorbidity
1st Line: Amoxicillin 1 mg PO TID x 5-7 days OR Doxycycline 100mg PO BID x 5-7 days
Alternative: Azithromycin (Z-Pack) daily x 5 days OR
Clarithromycin BID or extended-release 1,000 mg daily
With Comorbidity
Combination therapy: amoxicillin clavulanate (Augmentin) 1,000/62.5 mg PO BID OR Cephalosporin cefpodoxime (Vantin) or cefuroxime (Ceftin) PLUS azithromycin (Z-pack) or Clarithromycin (Biaxin) 500mg BID x 5-7 days
Alternative: Moxifloxacin (Avelox) 400 mg PO once a day
Gemifloxacin (Factive) 400 mg PO once a day

37
Q

COPD treatment

A

SABA→LAMA →LABA →ICS →Refer to pulmonologist.
* SABA (PRN): Albuterol, levalbuterol. (use with caution, may cause cardiac SE).
* LAMA: tiotropium (Spiriva). SAMA: Ipratropium (Atrovent).
* LABA: Salmeterol, formoterol, vilanterol.

38
Q

Asthama

A

Tx:
* SABA: rescue only, monitor usage.
* LABA,ICS: must be taken daily in order to work.
* Exercise induced asthma: SABA 15min before activity.

39
Q

To confirm RSV, two tests commonly used:

A

real-time reverse transcriptase-polymerase chain reaction (rRT-PCR), which is more sensitive than culture, and antigen testing, which is highly sensitive in children but not sensitive in adults

40
Q

Salmeterol is a

A

long acting beta agonist (Serevent diskus)

41
Q

most common pathogen that causes atypical pneumonia is

A

mycoplasma

42
Q

most common pathogen for CAP worldwide is

A

S pneumoniae

43
Q

most preferred abx for CAP is

A

macrolide -azithromyocin

44
Q

Pertussis is known as the

A

whooping cough

45
Q

Tdap should be given between what ages

A

11 - 12

46
Q

FEV1 stand for

A

forced expiratory volume in 1 second, volume of air that is forcefully exhaled in the first second of exhalation after a deep breath

47
Q

The most recent evidence based guidelines tx for CAP is

A

Amoxicillin 1 gm three times a day

48
Q

what is the mechanism of action of ipratropium

A
49
Q

Initial abx treatment of atypical community acquired pneumonia is a

A

macrolide (azithromyocin)

50
Q

the drug of choice for empiric treatment of S pneumoniae is

A

amoxicillin

51
Q

PCV13 is given at age60 and

A

every 5 years and PCV13 should be given one year later

52
Q

patients with asthma who only cough this is called

A

cough variant asthma

53
Q
A