Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Naplex > Rx Files ARVs > Flashcards

Rx Files ARVs Flashcards

1
Q

Zidovudine brand

A

Retrovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Zidovudine common name

A

AZT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Retrovir common name

A

AZT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

AZT mechanism of action

A

Thymidine analog which interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

AZT dosing

A

200 mg PO TID

300 mg PO BID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

AZT has _____ CNS penetration. (___%)

A

good

60%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drugs increase AUC of AZT?

A

clarithromycin
VPA
Lamivudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

AZT antagonizes what other ARV?

A

Stavudine (Zerit)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Adverse effects of AZT

A
  • severe anemia
  • headache
  • malaise
  • GI upset
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When taking AZT at what lab value should it be discontinued?

A

Hgb < 7.5 g/dL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Didanosine EC

A

Videx EC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Didanosine mechanism of action

A

Converted within cells to the mono, di, and triphosphates of dideoxyadenosine (dda). These dda phosphates bind to and inhibit reverse transcriptase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Didanosine adverse effects

A
  • peripheral neuropathy
  • pancreatitis
  • lipodystrophy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Didanosine drug interactions

A

Truvada

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Stavudine brand

A

Zerit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Stavudine mechanism of action

A

binds to and inhibits reverse transcriptase enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Stavudine dosing

A

weight based

  • < 60 kg: 30 mg PO BID
  • > 60 kg 40 mg PO BID
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Stavudine has ____ CNS penetration (___%)

A

good

30-40%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Stavudine adverse effects

A
  • peripheral neuropathy

- most likely of NRTIs to be associated with lactic acidosis and lipodystrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Stavudine drug interactions

A

AZT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Lamivudine brand

A

Epivir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Lamivudine mechanism of action

A

phosphorylates, binds to, and inhibits reverse transcriptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Lamivudine has rapid resistance to what (more/less) viable viral form?

A

less

M184V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What dosage form is Lamivudine available in?

A

oral solution and oral tablet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Lamivudine adverse effects

A

headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Lamivudine has efficacy against what other virus? What dose?

A

Hep B

Epivir-HBV 100 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Emtricitabine brand

A

Emtriva

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Emtricitabine is the once daily analogue of what other ARV?

A

Lamivudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Emtricitabine has efficacy against what other virus?

A

Hep B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Abacavir brand

A

Ziagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Abacavir adverse effect

A

hypersensitivity (major)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Is it recommended to re-challenge abacavir hypersensitivity?

A

never
never
never

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What are the nucleoSide reverse transcriptase inhibitors? NRTIs

A
  • Zidovudine
  • Didanosine
  • Stavudine
  • Lamivudine
  • Emtracitabine
  • Abacavir
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What are the nucleoTide reverse transcriptase inhibitors?

A
  • tenofovir

- tenofovir alfenamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Tenofovir brand

A

Viread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Tenofovir and tenofovir alfenamide have efficacy against what other virus?

A

Hep B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Tenofovir dosing

A

300 mg PO QD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Tenofovir drug interactions

A
  • didanosine EC

- atazanavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Tenofovir should be used cautiously in what condition?

A

renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What is the difference between tenofovir and tenofovir alfenamide?

A 
TDF = higher dose, larger tablet, more adverse effects
TAF = higher intercellular concentrations with fewer adverse effects, smaller dose, smaller tablet
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Tenofovir alfenamide is only available as what?

A

combination products

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What are the combination products containing tenofovir alfenamide?

A

Descovy
Odefesy
Genvoya

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What drugs are in Combivir?

A

300 mg AZT and 150 mg lamivudine

44
Q

How is Combivir dosed?

A

BID

45
Q

What drugs are in Trizivir?

A

150 mg lamivudine
300 mg AZT
300 mg abacavir

46
Q

How is Trizivir dosed?

A

BID

47
Q

What drugs are in Truvada?

A

200 mg Emtricitabine

300 mg Tenofovir

48
Q

What drugs are in Descovy?

A

200 mg Emtricitabine

25 mg Tenofovir Alfenamide

49
Q

Descovy has (more/fewer) adverse effects compared to Truvada. Why?

A

fewer - tenofovir alfenamide instead of tenofovir

50
Q

What drugs are in Epzicom?

A

300 mg Lamivudine

600 mg abacavir

51
Q

How is Epzicom dosed?

A

daily

52
Q

What drugs are in Atripla?

A

200 mg Emtricitabine
300 mg Tenofovir
600 mg Efavirenz

53
Q

How is Atripla dosed?

A

daily at bedtime

54
Q

What drugs are in Complera?

A

200 mg Emtricitabine
300 mg Tenofovir
25 mg Rilpivirine

55
Q

How is Complera dosed?

A

daily

56
Q

What is Complera nicknamed?

A

B-tripla in reference to its similarity to Atripla

57
Q

What drugs are in Stribild?

A

200 mg Emtricitabine
300 mg Tenofovir
150 mg elvitegravir
150 mg cobicistat

58
Q

What is the function of cobicistat in Stribild?

A

favorable drug interaction

59
Q

How is Stribild dosed?

A

daily

60
Q

What is the nickname of Stribild?

A

QUAD

61
Q

What drugs are in Triumeq?

A

300 mg Lamivudine
600 mg Abacavir
50 mg dolutegravir

62
Q

How is Triumeq dosed?

A

daily

63
Q

What drugs are in Genvoya?

A

200 mg Emtricitabine
25 mg Tenofovir alfenamide
150 mg elvitegravir
150 mg cobicistat

64
Q

Genvoya is the tenofovir alfenamide replacement for which combo product?

A

Stribild

65
Q

What drugs are in Odefesy?

A

200 mg Emtricitabine
25 mg Tenofovir alfenamide
25 mg rilpivirine

66
Q

Odefesy is the tenofovir alfenamide replacement for which combo product?

A

Complera

67
Q

Saquinavir brand

A

Invirase

68
Q

How must saquinavir be taken?

A

with a high fat meal or favorable drug interaction

69
Q

What drug creates a favorable drug interaction with saquinavir?

A

ritonavir (CP 450 system)

70
Q

What is the typical dose of saquinaivir?

A

500 mg BID with ritonavir 100 mg

71
Q

Ritonavir brand

A

Norvir

72
Q

Saquinavir adverse effects

A

GI intolerance

73
Q

What are the drug interactions with saquinavir?

A
  • terfenadine
  • cisapride
  • astemizole
  • triazolam
  • midazolam
  • ergot derivatives
  • rifampin
  • rifabutin
74
Q

What are the adverse effects of Ritonivir?

A
  • GI intolerance
  • circumoral and peripheral parathesias
  • increase in total cholesterol and TG levels
75
Q

Ritonivir is a very potent what?

A

enzyme inhibitor

76
Q

Indinavir brand

A

Crixivan

77
Q

Nelfinavir brand

A

Viracept

78
Q

Fosamprenavir brand

A

Lexiva

79
Q

Lopinavir/Ritonavir brand

A

Kaletra

80
Q

What is the most common side effect with Nelfinavir and how is it treated?

A

GI upset

OTC loperamide

81
Q

With Indinavir use, what lab value is often altered?

A

10% of patients experience increase in indirect dilirubin

82
Q

Atazanavir brand

A

Reyataz

83
Q

When should atazanavir be discontinued?

A

LFTs > 5x normal

84
Q

Atazanavir/Cobicistat

A

Evotaz

85
Q

Tipranavir brand

A

Aptivus

86
Q

Darunavir brand

A

Prezista

87
Q

Darunavir/Cobicistat

A

Prezcobix

88
Q

What are the Protease Inhibitors (PIs)?

A
  • Saquinavir
  • Ritonavir
  • Indinavir
  • Nelfinavir
  • Fosamprenavir
  • Lopinavir/Ritonavir
  • Atazanavir
  • Tipranavir
  • Darunavir
89
Q

Nevirapine brand

A

Viramune

90
Q

Nevirapine mechanism of action

A

binds to and inhibits the reverse transcriptase enzyme without requiring phosphorylation

91
Q

Nevirapine dosing

A

200 mg PO QD x 2 weeks than 200 mg PO BID

92
Q

When should Nevirapine be discontinued?

A

rash - risk of SJS

93
Q

Nevirapine drug interactions

A
  • indinavir
  • saquinavir
  • oral contraceptives
94
Q

Nevirapine black box warning

A

hepatic failure

95
Q

Efavirenz brand

A

Sustiva

96
Q

Efavirenz dosing

A

600 mg Qhs

97
Q

Efavirenz adverse drug reactions

A
  • CNS disengagement

- vivid nightmares

98
Q

Etravirine brand

A

Intelllence

99
Q

Etravirine dosing

A

200 mg PO BID

100
Q

Etravirine adverse drug reactions

A
  • rash

- diarrhea

101
Q

What is Etravirine’s place in therapy

A

salvage therapy

102
Q

What are the Non-nucleoside reverse transcriptase inhibitors (NNRTIs)?

A
  • Nevirapine
  • Efavirenz
  • Etravirine
103
Q

Cobicistat brand

A

Tybost

104
Q

Cobicistat inhibits what enzymes?

A

CP 450

105
Q

HIV counselling points

A
  1. Adherence is critical
  2. do not stop taking any medication unless directed to do so
  3. Talk to healthcare professionals before starting any other med
  4. Use caution when taking alternative or herbal remedies
  5. These drugs are NOT cures for HIV/AIDS
  6. Always encourage safe sex
  7. Length of treatment is indefinite

Naplex (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions