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Oral Biology II COPY > Salivary Glands > Flashcards

Salivary Glands Flashcards

1
Q

From what tissue layer are salivary glands derived?

A

Ectoderm

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2
Q

What are the 5 stages of salivary gland development?

A 
1-Prebud
2-Initial bud
3-Psuedoglandular
4-Canalicular
5-Terminal bud
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3
Q

What tissue is responsible for the branching of salivary glands?

A

Salivary mesenchyme

*interacts with salivary epithelium to create the salivary gland

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4
Q

During the canalicular stage, what process must take place in surrounding tissues to make room for the lumen? What transcription factor helps the cells that make up the tubules to survive?

A

Caspase mediated apoptosis

survivin helps ensure the survival of the tubular cells

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5
Q

Salivary gland development depends on what two neurotransmitters? Where are those neurotransmitters released from?

A

1-Acetylcholine (parasympathetic from otic ganglion at the time of gland formation)
2-Norepinephrine (sympathetic from efferent nerves in the cervical ganglion)

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6
Q

What stages go wrong when aplasia of lacrimal and salivary glands results?

A

Pre-bud to initial bud

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7
Q

Which stages go wrong when lacrimoauriculodentodigital syndrome happens?

A

Initial bud to pseudoglandular

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8
Q

Which stage goes wrong to result in hizohidrotic ectodermal displasia?

A

Canalicular stage

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9
Q

What are the 3 major salivary glands through which 90% of saliva is made?

A

1-Parotid gland (mainly serous)
2-Submandibular gland (mixed serous and mucous)
3-Sublingual gland (mainly mucous)

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10
Q

The outside of an acinus is called?

A

Basolateral

*Inside is apical

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11
Q

Which cells stain lighter and has flat nuclei?

A

Mucous cells

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12
Q

Which cells secrete watery saliva?

A

Serous cells

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13
Q

Where are stem cells and progenitor cells found?

A

Intercalated duct

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14
Q

Where is saliva modified?

A

Striated duct

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15
Q

Which neurotransmitter is associated with the parasympathetic nervous system, M3R receptor, Gq protein, Phospholipase C, and IP3?

A

Acetylcholine

*water and fluid secretions

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16
Q

Which neurotransmitter is associated with the sympathetic nervous system, B-adrenergic receptor, Gs protein, Adenylyl cyclase and cAMP?

A

Norepinephrine

17
Q

What are the 2 stages of saliva secretion?

A

1-Fluid secretion (Acinus)

2-NaCl reasorption and K secretion (Ducts)

18
Q

What are the two main kinds of protein secretion?

A

1-Constitutive (secretion through vesicles)

2-Regulated pathways (neurotransmitter dependent rapid release of granules)

19
Q

Which receptor is stimulated by neurotransmitters (mainly norepi) to exocytose large secretory granules?

A

B-adrenergic

20
Q

EGF levels are high during which stage of salivary gland development?

A

Terminal Bud stage

21
Q

parasympathetic innervation for salivary glands develops when? what about sympathetic innervation?

A

parasympathetic before birth

sympathetic after

22
Q

sympathetic innervation of salivary glands causes what kind of secretion?
parasympathetic?

A

symp - protein

para - water

23
Q

what is the parasympathetic neurotransmitter? what is the receptor for it on salivary glands? what cell surface proteins does that receptor activate? which activates what enzyme and what second messenger?

A 
Acetylcholine
M3R receptor
Gaq - cell surface protein
PLC - enzyme
IP3 - SEcondary messenger
24
Q

what is the sympathetic neurotransmitter? what is the receptor for it on salivary glands? what cell surface proteins does that receptor activate? which activates what enzyme and what second messenger?

A 
Norepinephrince
Beta Adrenergic receptor
Gas - cell surface protein
Adenylyl cyclase - enzyme
cAMP - secondary messenger
25
Q

what is the two stage hypothesis for salivary maturation?

A

in the acinus the secretion is in its first stage and it is hypertonic with NaCl. Then it travels down the tubules and NaCL is taken out and K+ and Bicarb are put in and is hypotonic during this second stage

26
Q

what allows for one way secretion of water and saliva?

A

tight junctions

27
Q

T/F ducts are impermeable to water?

A

true

Oral Biology II COPY (15 decks)

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