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PharmEx2 > Side Effects > Flashcards

Side Effects Flashcards

1
Q

Anaphylaxis

Rash

A

PCNs

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2
Q

Diarrhea & superinfection

A

Cephalosporins (diarrhea more common amp>amox)

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3
Q

Allergy (less sever than PCNs) and cross sensitivity with PCNs <1%

A

Cephalosporins

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4
Q

Which gen cephalosporin causes diarrhea?

A

1st (cephalexin (PO)

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5
Q

Which gen cephalosporin causes superinfection and possibly DDI: enhancement of warfarin?

A

2nd gen (cefuroxime)

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6
Q

Which gen cephalosporin causes superinfection? And also penetrates CNS well

A

3rd gen

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7
Q

Infusion related: chills/fever/rash (redman syndrome), ototoxicity, renal toxicity & needs *routine monitoring of Cp levels

A

Vanco

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8
Q

GI disturbances, DD interactions due to inhibition of P450 metabolism (not azith)

A

Macrolides (CE)

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9
Q

Abnormal bone/tooth development (avoid in children and pregnancy), fungal superinfection, DDIs with antacids & dairy

A

Tetracyclines

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10
Q

Severe diarrhea and pseudomembrane colitis

A

Loose stool linda

Clinda

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11
Q

Vestibular and auditory toxicity, nephrotoxicity and *need routine monitoring of Cp levels

A

Aminoglycosides (micin/mycin)

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12
Q

Potential for serious ARDS, superinfections, DDI with theophylline and antacids

Rare: CNS disorders, inc QT interval, give children ARTHRALGIAS

A

Fluoroquinolones (Cipro, levo, moxi)

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13
Q

GI side effects, microcrystalline forms better tolerated

A

Nitro

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14
Q

Nausea, HA, GI distress, antabuse like rxn and occasional candidial superinfections

A

Metronidazole

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15
Q

Hypersensitivity skin reactions, kernicterus in neonates, renal crystalluria via H20 solubility of metabolites

A

Sulfas

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16
Q

Allergic rxn, hepatotoxicity, neuritis tx with vit B6

A

Isoniazid isoniazide inhibits

17
Q

Liver fxn impairment, colors secretions orange-red, inducer of CYP1A2

A

Rifampin rifampin RAMPS up

18
Q

Optic neuritis (avoid in children)

A

Ethambutol

19
Q

Hepatotoxicity, hyperuricemia (gout)

A

Pyrazinamide

20
Q

Acute: fever, chills, on infusion (red man synd), nephrotoxicity, anemia

A

Amphotericin B

21
Q

Well tolerated topically but upset GI if PO

A

nystatin

22
Q

Well tolerated (GI upset), least effect onCPY450

A

Fluconazole

23
Q

Anorexia, hepatotoxicity, inhibits P450 and androgen-GC biosynthesis

A

Clotrimazole/Miconazole

24
Q

HA, diarrahea, rash, some DDIs with CPY450 substrates

A

Terbinafine

25
Q

N/V and an antiviral

A

Oseltamivir

26
Q

Bronchospasm and antiviral

A

Zanamivir

27
Q

Well tolerated and less n/v than oseltamivir

A

Baloxavir

PharmEx2 (3 decks)

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