Siklus Krebs Flashcards

1
Q

Enzim yang mengatalisis dekarboksilasi oksidatif (konversi piruvat → asetil-KoA) adalah?

A

Kompleks pyruvate dehydrogenase (PDH)

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2
Q

Enzim yang berperan sebagai regulator kompleks PDH adalah?

A

Pyruvate dehydrogenase kinase

Pyruvate dehydrogenase phosphatase

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3
Q

Step 1 dekarboksilasi oksidatif

A

Piruvat → CO2 + Asetil

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4
Q

Enzim yang mengatalisis step 1 dekarboksilasi oksidatif

A

Pyruvate dehydrogenase

Koenzim: thiamine pyrophosphate (TPP)

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5
Q

Asetil + TPP

A

Hydroxyethyl TPP (HETTP)

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6
Q

Step 2 dekarboksilasi oksidatif

A

Oksidasi HETTP dan transfer asetil dari TPP ke asam lipoat

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7
Q

Enzim yang mengatalisis step 2 dekarboksilasi oksidatif

A

Dihydrolipoil transacetylase

Koenzim: asam lipoat

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8
Q

Yang berperan sebagai oksidator pada step 2 dekarboksilasi oksidatif

A

Asam lipoat (gugus disulfida)

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9
Q

Step 3 dekarboksilasi oksidatif

A

Transfer asetil ke koenzim A

Asam lipoat → dihidrolipoamin

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10
Q

Enzim yang mengatalisis step 3 dekarboksilasi oksidatif

A

Dihydrolipoil transacetylase

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11
Q

Step 4 dekarboksilasi oksidatif

A

Reoksidasi asam lipoat

(dihidrolipoamin → asam lipoat); recover gugus disulfida

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12
Q

Enzim yang mengatalisis step 4 dekarboksilasi oksidatif

A

Dihydrolipoil dehydrogenase

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13
Q

Oksidator dalam step 4 dekarboksilasi oksidatif

A

NAD+

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