SIRS, SEPSIS, SEPTIC SHOCK

Question 1

SIRS criteria include ___.

Answer 1

-Temp > 100.4 (38) or < 96.8 (36)
*pSIRS temp > 101.3 (38.5) or < 96.8 (36)

-HR > 90
*pSIRS: ↑HR, or bradycardia in < 1 yr age groups

-RR > 20 or PaCO2 < 32 mmHg
*pSIRS: ↑RR, or mech. ventilation

-WBC > 12,000/mm3, or < 4000/mm3, or > 10% band forms
*pSIRS: abnormal leukocyte count or > 10% bands.

*for pediatric SIRS (pSIRS): 2 required (1 must be abnormal temp or leukocyte count).

Question 2

Sepsis criteria include __.

Answer 2

SIRS
+
suspected or known source of infection.

Question 3

Severe sepsis criteria include __.

Answer 3

Sepsis (SIRS + suspected/known source of infection)
+
Organ dysfunction
+
Hypotension (SBP < 90 or SBP drop ≥ 40)
+
Hypoperfusion (Lactic acidosis)

Question 4

Septic shock criteria include ___.

Answer 4

Severe sepsis with hypotension despite fluid resuscitation.

Question 5

Multiple organ dysfunction syndrome (MODS) is defined as ___.

Answer 5

e/o ≥ 2 organs failing