Sjogren's Syndrome

Question 1

What is Sicca Syndrome?

Answer 1

Partial Sjogrens findings (dry eyes or dry mouth but not both)

Question 2

What is primary Sjogrens syndrome?

Answer 2

No connective tissue disease is present

Question 3

What is secondary Sjogrens syndrome?

Answer 3

• dryness with associate connective tissue disease
• lupus, rheumatoid arthritis, scleroderma

Question 4

What sex is more likely to suffer from Sjogrens disease?

Answer 4

women 10:1 men

Question 5

What risk is associated with pregnancy in Sjogrens syndrome patients?

Answer 5

Neonatal lupus in baby

Question 6

What are some potential aetiological factors of Sjogrens Syndrome?

Answer 6

• low oestrogen in women
• incomplete cell apoptosis leads to antigens being improperly executed
• dysregulation of inflammatory process

Question 7

What are some consequences of Sjogrens syndrome?

Answer 7

• gradual loss of salivary/lacrimal gland tissue through inflammatory destruction
• enlargement of major salivary glands
• increased risk of lymphoma
• oral & ocular effects of loss of saliva & tears

Question 8

What scoring systems are in use for detecting Sjogrens syndrome?

Answer 8

• American-European Consensus Group (2002)
• ACR-EULAR joint criteria (2016)

Question 9

How many of the objective/subjective findings does a patient need to have to be diagnosed with Sjogrens Syndrome?

Answer 9

at least 4 of the findings

Question 10

What is the summary of a patient with Sjogrens Syndrome via the AECG pathway?

Answer 10

• Dry eyes/mouth (subjective or objective)
• autoantibody findings
• imagine findings
• histopathological findings
  *FOUR OR MORE OF THESE