Skin Cancer Flashcards
Clinical Features of BCC
- Pearly edges
central ulceration and bleeding
Often face and head = chronic sun exposure ○ e.g. inner cathus of eye
Locally aggressive but rarely mets
Can present like a red plaque - not responding to steroids
Clinical features of SCC
- Raised, indurated - Tender - Crusted lesion - Bleeds easily - Areas of sun exposure ○ Also associated with HPV, immunosuppression Worse prognosis if immunosuppressed or morphoeic sub-type/morphology
Features of Melanoma
- Itchy
- Increasing in size
- Raised
- Darkly pigmented
- Heterogenous colours
- Irregular borders
- Crusting and bleeding
- asymmetrical
Identify this lesion
Seborrheic keratosis
Identify this lesion
Squamous Cell Carcinoma
Identify this lesion
Melanoma
Identify this lesion
Basal Cell Carcinoma
What is Bowen’s Disease?
SCC in situ, significant potential for lateral spread.
Mx - topical treatment e.g. imiquimod or surgical excision if resistant to treatment or suspicious for SCC
What are Solar Keratosis?
Pre-mlaignant (but non-invasive) epidermal dysplasia.
They have mild-moderate dysplasia and can give rise to SCC or BCC.
Clinical presentation:
- erythematous, scaly lesions
- often on dorsum of hands
- beware of a growing, hyper-keratotic nodule amongst actinic/solar keratosis as this can be a sign of malignant transformation.
How are solar keratosis managed
- Cryotherapy
- Topical treatments
- Biopsy any areas of change
- Surgical excision
What is Seborrheic Keratosis
A benign, pigmented lesion (though can also have crusty/warty appearance).
Histology: proliferation of basaloid cells, no significant nuclear pleiomorphism or mitotic activity.
They are above the leve of the epidermis, do NOT invade the dermis.
Considered benign - if Bx, excisional is preferred.
DDx - melanocytic lesion, naevi, dermato-fibroma
