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Y2 LCRS Pharm HR COPY > SNS antagonists > Flashcards

SNS antagonists Flashcards

1
Q

What are the 2 main roles of alpha 1 adrenoceptors?

A

Vasoconstriction + GIT relaxation

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2
Q

What subtype of G protein are alpha 1 adrenoceptors linked to?

A

Gq

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3
Q

What are the 2 main roles of alpha 2 adrenoceptors?

A

Neg. feedback at presynaptic terminal

CNS actions

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4
Q

What subtype of G protein are alpha 2 adrenoceptors linked to?

A

Gi

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5
Q

What are the 2 main roles of beta 1 adrenoceptors?

A
  1. Increase HR and contractility

2. Increase renin release

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6
Q

What are the 2 main roles of beta 2 adrenoceptors?

A

Bronchodilation

Vasodilation

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7
Q

What is the main role of beta 3 receptors?

A

Lipolysis

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8
Q

Give an example of a selective alpha 1 agonist

A

Prazosin

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9
Q

What is the main clinical use of alpha antagonists?

A

TPR decrease

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10
Q

Give an example of a non-selective alpha antagonist

A

Phentolamine

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11
Q

Where do non-selective antagonists act other than alpha receptors?

A

Baroreceptors

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12
Q

Why is it clinically relevant that phentolamine acts on both alpha 2 aderenoceptors and baroreceptors?

A

Reduced effectiveness as alpha 2 antagonism reduced BP but then baroreceptor stimulation increases it again

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13
Q

What is the main side effect of phentolamine and why?

A

Major SE = GI effects due to inhibition of SNS tone -> diarrhoea

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14
Q

Give 2 examples of selective beta 1 antagonists

A

Atenolol, nebivolol

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15
Q

What is the main clinical use of beta-1 antagonists?

A

Anti-hyertensives

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16
Q

Recall 6 possible side effects of beta-2 antagonists

A
  1. Bronchoconstriction (caution: asthma)
  2. Hepatic glucose release (caution: diabetics)
  3. Reduced SNS action in heart (caution: heart failure)
  4. Fatigue
  5. Cold extremities
  6. Bad dreams due to CNS effects
17
Q

Give 2 examples of non-selective beta antagonists

A

Propanolol

Carvedilol

18
Q

Recall the selectivity of carvedilol

A

Beta 1, beta 2, alpha 1

19
Q

Recall an advantage and a disadvantage of carvedilol use

A

Advantage: antagonises beta and alpha 1 receptors so pronounced effect on BP
Disadvantage: significant side effect profile

Y2 LCRS Pharm HR COPY (31 decks)

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