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*STEP 1 FACTS > STEP 1 FACTS > Flashcards

STEP 1 FACTS Flashcards

1
Q

HLA SUBTYPE:
A-3

ASSOCIATION:

A

Hemochromatosis

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2
Q

HLA SUBTYPE:
B27

ASSOCIATION:

A

Seronegative arthropathies (PAIR):

  1. Psoriatic arthritis
  2. Ankylosing spondylitis
  3. Inflammatory bowel disease
  4. Reactive arthritis (Reiter syndrome)
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3
Q

HLA SUBTYPE:
DQ2/DQ8

ASSOCIATION:

A

Celiac disease

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4
Q

HLA SUBTYPE:
DR2

ASSOCIATION:

A
  1. SLE
  2. Multiple sclerosis
  3. Goodpasture syndrome
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5
Q

HLA SUBTYPE:
DR3

ASSOCIATION:

A
  1. SLE
  2. DM type I
  3. Graves disease
  4. Hashimoto thyroiditis
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6
Q

HLA SUBTYPE:
DR4

ASSOCIATION:

A
  1. DM type 1

2. Rheumatoid arthritis

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7
Q

HLA SUBTYPE:
DR5

ASSOCIATION:

A
  1. Pernicious anemia

2. Hashimoto thyroiditis

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8
Q

AUTOANTIBODY:
Anti-AChR

ASSOCIATION:

A

Myasthenia gravis

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9
Q

AUTOANTIBODY:
Anti-BM

ASSOCIATION:

A

Goodpasture syndrome

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10
Q

Goodpasture syndrome

- Principle target of anti-BM autoantibody

A

Alpha3-chain type IV collagen

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11
Q

Antiphospholipid syndrome

- Autoantibody (3)

A
  1. Anti-cardiolipin
  2. Lupus anticoagulant
  3. Anti-beta2 glycoprotein
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12
Q

AUTOANTIBODY:
Anti-centromere

ASSOCIATION:

A

Scleroderma (CREST syndrome)

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13
Q

AUTOANTIBODY:
Anti-Scl70

ASSOCIATION:

A

Scleroderma

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14
Q

Anti-Scl70 =

A

Anti-topoisomerase I

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15
Q

AUTOANTIBODY:
Anti-desmoglein 1/3

ASSOCIATION:

A

Pemphigus vulgaris

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16
Q

AUTOANTIBODY:
Anti-dsDNA

ASSOCIATION:

A

SLE

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17
Q

AUTOANTIBODY:
Anti-Sm

ASSOCIATION:

A

SLE

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18
Q

AUTOANTIBODY:
Anti-glutamic acid decarboxylase (GAD)

ASSOCIATION:

A

DM type I

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19
Q

AUTOANTIBODY:
Anti-hemidesmosome

ASSOCIATION:

A

Bullous pemphigoid

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20
Q

AUTOANTIBODY:
Anti-histone

ASSOCIATION:

A

Drug-induced lupus

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21
Q

AUTOANTIBODY:
Anti-Jo-1

ASSOCIATION:

A
  1. Dermatomyositis

2. Polymyositis

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22
Q

Anti-Jo-1 =

A

Anti-histidyl tRNA synthetase

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23
Q

AUTOANTIBODY:
Anti-SRP

ASSOCIATION:

A

Polymyositis

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24
Q

Anti-SRP =

A

Anti-signal recognition particle

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25
Q

AUTOANTIBODY:
Anti-Mi-2

ASSOCIATION:

A

Dermatomyositis

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26
Q

Anti-Mi-2 =

A

Anti-helicase

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27
Q

AUTOANTIBODY:
Anti-microsomal

ASSOCIATION:

A

Hashimoto thyroiditis

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28
Q

AUTOANTIBODY:
Anti-thyroglobulin

ASSOCIATION:

A

Hashimoto thyroiditis

29
Q

AUTOANTIBODY:
Anti-mitochondrial

ASSOCIATION:

A

Primary biliary cirrhosis

30
Q

AUTOANTIBODY:
Anti-smooth muscle

ASSOCIATION:

A

Autoimmune hepatitis

31
Q

AUTOANTIBODY:
Anti-actin

ASSOCIATION:

A

Autoimmune hepatitis

32
Q

AUTOANTIBODY:
Anti-SSA (Anti-Ro) + Anti-SSB (Anti-La)

ASSOCIATION:

A

Sjogren syndrome

33
Q

AUTOANTIBODY:
Anti-TSH receptor

ASSOCIATION:

A

Graves disease

34
Q

AUTOANTIBODY:
Anti-U1 RNP

ASSOCIATION:

A

Mixed connective tissue disease

35
Q

Anti-U1 RNP

A

Anti-U1 ribonucleoprotein

36
Q

AUTOANTIBODY:
(2)

ASSOCIATION:
Celiac disease

A
  1. IgA anti-endomysial

2. IgA anti-tissue transglutaminase (tTG)

37
Q

AUTOANTIBODY:
C-ANCA

ASSOCIATION:

A

Granulomatosis with polyangiitis (Wegener)

38
Q

C-ANCA =

A

MPO-ANCA

MPO = myeloperoxidase

39
Q

AUTOANTIBODY:
P-ANCA

ASSOCIATION:

A
  1. Microscopic polyangiitis

2. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

40
Q

P-ANCA =

A

PR3-ANCA

PR3 = proteinase 3

41
Q

AUTOANTIBODY:
Anti-CCP

ASSOCIATION:

A

Rheumatoid arthritis

42
Q

Anti-CCP =

A

Anti-cyclic cirtullinated peptides

43
Q

Rheumatoid factor =

A

IgM antibody that targets Fc region of IgG

44
Q

CONDITION:
Actinic keratosis

ASSOCIATED NEOPLASM:

A

Actinic keratosis predisposes to SCC of the skin

45
Q

CONDITION:
Dysplastic nevus

ASSOCIATED NEOPLASM:

A

Dysplastic nevus predisposes to malignant melanoma

46
Q

CONDITION:
Dermatomyositis + polymyositis

ASSOCIATED NEOPLASM:

A

Visceral malignancies, especially genitourinary

47
Q

Psammoma bodies are a/w what 4 conditions?

A

Papillary thyroid cancer
Serous papillary cystadenocarcinoma of the ovary
Meningioma
Malignant mesothelioma

PSaMMoma

48
Q

Lipopolysaccharide

  • Lipid A
  • O polysaccharide
A

Lipid A - Induces IL-1, IL-6, TNFa

O-polysaccharide - Antigen

49
Q

Silver stain - 3 bugs

A

Legionella
H. pylori
Fungi

50
Q

India ink stain

A

Cryptococcus

Mucicarmine can also be used to stain thick polysaccharide capsule red

51
Q

CULTURE MEDIA:
Chocolate agar

BUG:
?

A

H. influenzae

52
Q

Chocolate agar - 2 components

A

Factor V (NAD+), factor X (hematin)

53
Q

CULTURE MEDIA:
Thayer-Martin agar

BUG:
?

A

Neisseria

54
Q

CULTURE MEDIA:
Lowenstein-Jensen agar

BUG:
?

A

M. tuberculosis

55
Q

CULTURE MEDIA:
Eaton agar

BUG:
?

A

M. pneumoniae

56
Q

CULTURE MEDIA:
Charcoal yeast extract agar + Cysteine + Iron

BUG:
?

A

Legionella

57
Q

CULTURE MEDIA:
Sabouraud agar

BUG:
?

A

Fungi

58
Q

CULTURE MEDIA:
Tellurite agar

BUG:
?

A

C. diptheriae

59
Q

Band neutrophils v. mature neutrophils

A

Decreased FcR expression (CD16)

60
Q

Drug to prevent mast cell degranulation

A

Cromolyn sodium

61
Q

Lymphocytic leukocytosis - Usually indicates viral infxn … 1 bacterial infxn as the exception?

A

Bordetella pertussis

62
Q

Site of EPO synthesis

A

Interstitial cells of peritubular capiilary bed

63
Q

Increased MCHC

A

Spherocytosis

64
Q

RDW

A

Reflects anisocytosis

Iron deficiency anemia

65
Q

TX of lead poisoning

  • Adults
  • Kids
A

ADULTS - Dimercaprol or EDTA

KIDS - Succimer

66
Q

Eosinophilia a/w

A 
Parasitic infxn
Hodgkin lymphoma (RS cells synthesize IL5)
67
Q

Basophilia a/w

A

CML

68
Q

Mono + ampicillin/penicillin –>

A

Rash

*STEP 1 FACTS (3 decks)

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