Step 2 Flashcards
what is happening in Laryngomalacia?
Intermittent collapse arytenoid cartilage during inspiration → increase turbulence of air → inspiratory stridor
When does stridor increase in laryngomalacia?
Stridor increases with crying and feeding (during increase air flow)
posterior dislocation of the humerus at the supracondylar level?
Supracondylar fracture → posterior dislocation of the humerus → damage to the median nerve and brachial artery.
anterior dislocation of humerus at supracondylar level?
Anterior dislocation of humerus → impingement of ulnar nerve ( rare form of supracondylar fracture)
Pheochromocytoma is associated with?
Pheochromocytoma is associated with VHL dx, MEN2, neurofibromatosis type 1
Treatment for frostbite
- rapid rewarming with warm bath.
2. Anelgesia and wound care. Thrombolysis in severe limb threatening cases
Treatment for mild hypothermia
passive external warming (remove wet clothes, cover with warm blankets
Treatment for moderate hypothermia
active external warming (warm blankets, heating pads, warm bath
treatment for severe hypothermia
active internal warming (warmed pleural or peritoneal irragation, warmified humified oxygen
Influenza complication for advanced age and chronic illness and Treatment?
Pneumonia → worse cough and dyspnea, leukocytosis, bilateral diffuse interstitial infiltrates on cxr.
Tx: hospitalization with supplemental oxygen and osteltamivir (antiviral)
Seizure + acute bacterial gastroenteritis should raise concerned for?
shigella
Ultrasound finding for Nonalcoholic fatty liver disease (NAFLD)
hypoechoic appearing liver which reflects hepatic fatty infiltrates
Criteria for Nonalcoholic fatty liver disease (NAFLD) and treatment
treatment?
Type 2 diabetes, obesity and elevated liver enzymes (AST/ALT <1)
treatment is weight loss
Mullerian agenesis is associated with?
associated with renal anomalies such as duplicated ureter so they need renal ultrasound
what to do after seeing HSIL on pap smear?
colposcopy
What to do if squamocolumnar junction cannot be seen or colposcopy is unsatisfactory?
endocervical curettage (endocervical sampling (sample tissue))
Genitopelvic pain/ penetration disorder (vaginismus)
feature?
Pain with attemped to vaginal penetration, inserting tampon, or during gyn examination
However no other medical problem
Genitopelvic pain/ penetration disorder Treatment?
desensitize therapy and kegel exercise
Acute hemolytic transfusion reaction
feature?
Fever, flank pain and dark urine after transfusion
what is the diagnostic test for acute hemolytic transfusion reaction?
direct coomb test
what is the treatment for acute hemolytic transfusion reaction?
stop transfusion, give fluid and supportive care
what is some complications from acute hemolytic transfusion reaction?
DIC and acute renal failure
Pt with chronic autoimmune disease such as SLE, sjogren dx are at risk for?
Non Hodgkin lymphoma due to persistent B cell stimulation and immune dysregulation
Lab finding = increased LDH
Friedreich’s ataxia symptoms?
Neurological dysfunction = loss of proprioception and vibration sense, ataxia, spastic weakness
Cardiomyopathy
DM
Scoliosis
who gets Anemia of prematurity?
premies
lab finding for anemia of prematurity?
what is the etiology?
Low hemoglobin, hematocrit and RBC but normocytic normochromic RBC
impaired ability to produce adequate erythropoietin (EPO)
Treatment for anemia of prematurity?
Tx: minimize blood draws, iron supplement and transfusion
which anticoagulant should be used for DVT/ PE patients with renal dx?
unfractionated heparin
Emphysematous cholecystitis treatment?
Surgical emergency → cholecystectomy now
Fever, RUQ pain, absent peritoneal signs with possible crepitus in the abdominal wall (rare)
Air fluid filled in gallbladder on U/S
Emphysematous cholecystitis
recurrent mild and unilateral mid cycle pain prior to ovulation. pain lasts hours to days
Mittelschmerz
amenorrhea, abdominal/pelvic pain, and vaginal bleeding
positive HCG
no intrauterine pregnancy on U/S
Ectopic pregnancy
sudden, onset severe unilateral lower abd pain, nausea and vomiting
unilateral tender adnexal mass on examination
ovarian torsion
what is the U/S finding for ovarian torsion?
enlarged ovary with decreased or absent blood flow
sudden onset severe unilateral lower abd pain right after strenuous exercise or sexual activity
rupture ovarian cyst
what is the U/S finding for rupture ovarian cyst?
pelvic free fluid
fever/chills, vaginal discharge, lower abd pain, and cervical motion tenderness
PID
Why is aldosterone not affected by Panhypopituitarism?
Aldosterone is not affected because it is regulated by RAAS and not hypopituitarism
Low T4, cortisol/ ACTH, FSH/LH for
Panhypopituitarism
Treatment for lichen planus?
topical high potency glucocorticoids
Seen on skin, oral mucosa, genitalia
how to diagnose and treat ovarian torsion?
U/S
emergency lap detorsion or cystectomy
treatment for prostatitis?
6 weeks of TMP- SMX or fluoroquinolone
diagnosis for prostatitis?
Diagnosis is confirmed by digital rectal exam (swollen tender prostate = anterior tenderness) but urine culture is needed to establish infected organism
C7 radiculopathy
Weakness in triceps extension and wrist flexion; numbness in index and middle fingers
C6 radiculopathy
Weakness in wrist extension and numbness in forearm and thumb
PPROM
<34 weeks (reassuring)
latent antibiotics, corticosteroids
PPROM
<34 weeks (nonreassuring)
delivery
PPROM
>34 weeks
delivery
neuroleptic malignant syndrome treatment
Stop antipsychotic or restart dopamine agent
Dantrolene or bromocriptine if refractory
neuroleptic malignant syndrome
Muscle rigidity, akinesia, tremor
Hyperthermia
Autonomic instability (tachycardia, labile blood pressure, tachypnea, diaphoresis, dysrhythmias)
Mental status change: confusion, delirium, reduced vigilance, stupor
pt has AF + acute limb ischemia. what is the treatment?
Treat with Factor Xa inhibitors (apixaban, dabigatran, rivarobaxan) to prevent embolic occluson such as acute limb ischemia
Oral anticoagulant
scaly plaques/nodules +/- hyperkeratosis or ulceration on skin
squamous cell carcinoma of skin
diagnosis for squamous cell carcinoma of skin
biopsy
dysplastic/ anaplastic keratinocytes
keratin pearls
a pregnant woman has ovarian torsion. what do you do for her and pregnancy?
Do oophorectomy
If the corpus luteum is removed before 10 weeks, must give progesterone to maintain pregnancy. Can discontinue after 10 weeks
progressive proximal muscle weakness and atrophy without pain or tenderness
normal ESR + CK
Glucocorticoids inducted myopathy
muscle pain and stiffness in shoulder and pelvic girdle
tenderness and decreased ROM at shoulder, neck and hip
respond with glucocorticoids
polymyalgia rheumatica
lab finding for polymyalgia rheumatica
elevated ESR and normal CK
negative rheumatoid factors and no autoantibodies
Normochromic anemia
Muscle pain, tenderness and proximal muscle weakness
skin rashes and inflammatory arthritis may be present
elevated ESR and CK
Polymyositis (PM): inflammatory myopathy affecting the proximal skeletal muscles
Dermatomyositis (DM): polymyositis, with the addition of skin involvement
Inclusion body myositis (IBM): both the proximal and distal skeletal muscles
prominent muscle pain/tenderness with or without weakness
rare rhabdomyolysis
statin induced myopathy
lab finding for statin induced myopathy
normal ESR and elevated CK
muscle cramps, pain, weakness of proximal muscles
delayed tendon reflex and myoedema
occasional rhabdomyolysis
features of hypothyroidism are present
hypothyroid myopathy
lab finding for hypothyroid myopathy
normal ESR and elevated CK
Sudden, severe loss of vision in the affected eye
funduscopic exam shows
dot-and-blot and/or flame-shaped hemorrhages in all four retinal quadrants
venous thickening (blood and thunder appearance)
Cotton wool spots
macular edema
Central retinal vein occlusion
Sudden, painless loss of vision in one eye (often described as a “descending curtain”)
funduscopic exam shows
Grayish-white (cloudy) discoloration of the entire retina
Cherry-red spot at the fovea centralis
Retinal plaques/emboli
A bruit over the carotid artery is a sign of carotid atherosclerosis.
An irregular pulse may indicate atrial fibrillation.
Scalp tenderness and/or jaw claudication is a sign of temporal arteritis.
central retinal artery occlusion
past hx of Amaurosis fugax
sudden, painless loss of vision that lasts for seconds to minutes and is followed by spontaneous recovery (mostly unilateral)
Amaurosis fugax
treatment for hyperemesis gravidarum
hospital admission
antiemetics and IV fluids
treatment for adjustment disorder
psychotherapy
Treatment for polymyositis?
Treatment for polymyositis includes glucocorticoids and glucocorticoids sparing agents such as methotrexate and azathioprine
Females (46 XX)
Birth: Ambiguous genitalia despite normal internal genital organs
Puberty: Impaired maturation of secondary sexual characteristics
Primary amenorrhea
Virilization (e.g., hirsutism, severe acne)
no ovarian mass
Aromatase deficiency
Drowning can cause?
ARDS and hypoxemia
what tumor marker is used to evaluate recurrence of thyroid cancer after thyroidectomy
Thyroglobulin
endometrial biopsy indication
> age 45
anyone with abnormal bleeding or postmenopausal bleeding
endometrial biopsy indication
< age 45
abnormal bleeding plus
unopposed estrogen (obesity, anovulation)
failed medical management
lynch syndrome (HNCR)
endometrial biopsy indication
< age 35
atypical granular cells on pap test
Irregular vaginal bleeding, pelvic pain and enlarged uterus + chest pain, hemoptysis and dyspnea
occur after pregnancy, abortion or hydatidiform mole
Choriocarcinoma
kids with Isolated speech delay; what is the next step?
hearing test
papule at scratch/bite site
regional adenopathy
+/- fever
cat scratch disease
bartonella henselae
Treatment for multiple sclerosis
high dose iv glucocorticoids
If unresponsive, use plasma exchange
Treatment for infant botulism
human derived botulism immune globulin
Treatment for foodborne botulism
equine derived botulism antitoxin
Treatment for idiopathic intracranial hypertension
Weight loss
acetazolamide
fever, irritability, limited function (limp), bone tenderness, swelling
elevated CRP, ESR, WBC count
osteomyelitis
definitive test for osteomyelitis
bone biopsy/ culture
Back pain, unilateral hearing loss (acquired), headache and femoral bowing
paget disease of bone
If lithium level is >2.5 or
Pt with lithium level >4 and creatine >2
treat with hemodialysis
Lithium toxicity
neurologic (AMS, seizure, fasciculation, ataxia, tremor) and GI signs (nausea and vomiting)
pregnant woman with syphilis treatment plan
Pregnant women should be desentized since doxycycline is contraindicated
Traveller with no vaccines who presents with nausea, vomiting, fever and abdomen pain followed by jaundice and pruritus
hepatitis A
Diagnosis of acute mesenteric ischemia
CT or MR angiography
abdomen pain out of proportion; leukocytosis, elevated amylase and phosphate level, elevated lactate (metabolic acidosis)
acute mesenteric ischemia
in acute mesenteric ischemia, how do you treat for hemodynamically unstable
emergency laparotomy
recurrent episodes of vertigo lasting 20 minutes to several hours
sensorineural hearing loss
Tinnitus and/or feeling fullness in the ear
meniere dx
treatment for meniere dx
salt restriction
pentamidine
alternative to TMP-SMX
Use during first trimester of pregnancy or in patients with sulfa drug allergy: atovaquone or dapsone
Cerebral toxoplasmosis treatment vs prophylaxis treatment
Treatment: Pyrimethamine + sulfadiazine + folinic acid (leucovorin)
Prophylaxis in patients with CD4+ T-cell count < 100 cells/μL: trimethoprim/sulfamethoxazole
primary CNS lymphoma is associated with which infection?
EBV
solitary ring-enhancing lesion on CT, EBV + on CSF suggest?
primary CNS lymphoma
treatment of CNS lymphoma
High dose methotrexate with/without whole brain radiotherapy
Oral/IV corticosteroids to control symptoms of raised ICP
colonoscopy finding on CMV colititis
linear ulcers
biopsy finding on CMV colitis
owl eyes; intracellular inclusions
CMV colitis clinical feature?
first step to do afterward?
CMV colitis typically presents with watery and explosive diarrhea, but if the distal colon becomes involved, the diarrhea may become bloody.
first step colonoscopy and owl eye inclusions on biopsy. to confirm
The presence of a hard mass just above the anal verge that bleed easily in an immunodeficient individual should raise suspicion of
anal carcinoma
treatment choice for anal carcinoma
The combination of chemotherapy and radiation is the treatment of choice for patients with anal squamous cell cancer
Treatment for aspiration pneumonia
Antibiotic treatment that covers anaerobes (e.g., ampicillin-sulbactam, carbapenems, or clindamycin)
metronidazole with amoxicillin, amoxicillin- clavulanate
treatment for PML
There is no specific treatment for PML. Supportive treatment and optimization of antiretroviral therapy is indicated
secondary malignancy that results from chronic lymphedema in patients who underwent radiation therapy and/or lymphadenectomy after mastectomy
Presents with multiple blue/purple, macular, and papular lesions in the area of the breast, chest wall, or upper extremity
lymphangiosarcoma
treatment for Bacillary angiomatosis
erythromycin or doxycycline
Bacillary angiomatosis
solitary or multiple, red, flesh-colored or colorless papules and nodules that bleed easily
+ Warthin-Starry stain is used to visualize bacilli and vascular proliferation on biopsy
Skin biopsy: spindle-shaped cells, leukocyte infiltration, and angiogenesis in HIV pt
Kaposi sarcoma (HHV 8) Malignant skin tumor associated with HIV
Treatment for Cryptosporidiosis
Antiparasitic therapy (e.g., nitazoxanide)
Treatment for Mycobacterium avium complex (MAC) infection
Macrolide (clarithromycin or azithromycin) plus ethambutol
Prevention of post-transplant infections
Universal prophylaxis
PCP prophylaxis with trimethoprim-sulfamethoxazole
CMV prophylaxis with ganciclovir or valganciclovir
contraindication to rotavirus vaccine
Rotavirus vaccine: severe combined immunodeficiency (SCID), history of intussusception; GI tract malformation (e.g., Meckel’s diverticulum)
ps: cystic fibrosis increased risk of intussusception
contraindication to pertussis- containing vaccines
unstable neurologic disorder (e.g., coma, uncontrolled seizures
contraindication to vaccinations
Severe, acute illness: e.g., infection with fever > 38.5°C (> 101.3°F)
Previous adverse reaction related to a vaccination: e.g. anaphylaxis
schedule vaccine for rotavirus
1st dose at 6 weeks
2nd dose at 4 months
3rd dose at 6 months
Hepatitis A vaccine recommendation
Hepatitis A vaccination is recommended for all children ages 12–23 months.
Current guidelines do not recommend HAV booster vaccination after successful primary immunization as it confers long-term immunity.
chickenpox vaccine recommendation
Live vaccine
Children: 1st dose at 12–15 months, 2nd dose at 4–6 years
Shingles vaccine recommendation
Live vaccine
≥ 50 years: zoster immunization is generally recommended
pneumococcal polysaccharide vaccine recommendation
For all adults age ≥ 65 with an immunocompromising condition, PCV13 vaccine followed by PPSV23 vaccine at least 8 weeks later is recommended.
pregnant with chronic hepatitis C
treatment
Individuals who have chronic liver disease such as hepatitis C can develop fulminant hepatitis if infected with hepatitis A. To prevent such complications, it is imperative that this woman receives the hepatitis A vaccine.
Combination therapy with ledipasvir/sofosbuvir and ribavirin or interferon a and ribavirin is indicated in patients with chronic hepatitis C infection. However, ribavirin has known teratogenic effects.
lung cancer screening
The US Preventive Services Task Force recommends annual screening for lung cancer with low-dose computed tomography (LDCT) in adults aged 55–80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years.
DTaP recommendation
The diphtheria and tetanus toxoids, acellular pertussis (DTaP) vaccine is given to children < 7 years of age as a 5-dose regimen at 2, 4, 6, and 15–18 months, and 4–6 years of age, respectively.
Hepatitis B vaccine recommendation
# of dose? what about low birth weight?
The hepatitis B vaccine is typically given as a 3-dose regimen, with the first dose administered at birth, the second dose at 1–2 months, and the third dose at 6 months.
because the production of protective anti-HBs antibodies in infants with low birth weight is weakened, infants < 2000 g should not receive their first dose until they are 1 month of age (regardless of birth weight) or discharged from the hospital.
Tdap in pregnancy
All pregnant women should receive a single dose of Tdap at 27–36 weeks of gestation regardless of the interval since the last Tdap or Td vaccination.
initial test to do to confirm SLE
1ST get ANA, ds DNA, anti smith
are complement high or low in SLE
Low
basic treatment for SLE
Hydroxychloroquine
pt has sle flare; how do you treat
glucocorticoid steroids
diagnostic test for lupus nephritis
kidney biospy “wire loop” capilaries
treatment for lupus nephritis
IV cyclophosphamide
po mycophenolate
felty syndrome
RA, splenomegaly and neutropenia
anti scl -70 (anti-topoisomerase 1 antibody)
Diffuse scleroderma
anti centromere
CREST
Treatment for scleroderma
organ specific; symptomatic therapy
raynaud = ccb
esophageal = ppi
scleroderma renal crisis = ACEi
horseness + multiple finger shaped lesions on true vocal cord
laryngeal pappilomas due to reccurent respiratory pappilomatosis
(look at image)
laryngeal pappiloma are caused by
HPV 6 and 11
endometrial polyps and menses
endometrial polyps usually have bleeding between regular monthly menstrual cycles. polyps does not cause amenorrhea
fibroids and menses
fibroids pt have heavy regular menstrual bleeding
Vulvar lichen planus
chronic inflammatory disorder that presents with multiple glazed erythematous vulvar erosions bordered by white striae (wickham striae)
serosanguinous discharge
Vulvar lichen planus treatment
topical glucocorticoids
maternal estrogen effects on newborns
breast hypertrophy
swollen labia
physiologic leukorrhea
uterine withdrawal bleeding
complications of primary biliary cholangitis
malabsorption, fat soluble vitamin deficiencies
metabolic bone dx (osteoporosis, osteomalacia)
hepatocellular carcinoma
primary sclerosis cholangitis association
ascending cholangitis and CRC
primary biliary cholangitis association
antimitochondrial antibodies and hyperlipidemia
first line treatment for ascites due to cirrhosis
furosemide and spinorolactone
when is large volume paracentesis indicated
when pt is respiratory compromise or severe abdomen pain
ascites