Stroke

Question 1

What is a mini stroke?

Answer 1

Transient ischaemic attack (TIA)

Question 2

What is plasmin?

Answer 2

Body’s own clot buster

Question 3

What is the only drug currently licensed for ACUTE ischaemic stroke?

Answer 3

Alterplase

Question 4

What is the role of aspirin?

Answer 4

Inhibit COX1

Prevent thromboxane formation

Question 5

What is the role of Dipyridamole?

Answer 5

Inhibit thromboxane synthase

Prevent thromboxane formation

Question 6

Dipyridamole is often used alongside what other drug?

Answer 6

Aspirin

Question 7

What is the mechanism of clopidogrel?

Answer 7

Antagonise actions of ADP at purinergic (ADP) receptors

Question 8

What is the role of Abciximab?

Answer 8

Prevent linking of platelets to fibres

Question 9

What are the 3 types of drug used for ischaemic stroke?

Answer 9

Fibrinolytic agents
Anti platelet drugs
Anti coagulant agents

Question 10

What is the mechanism of Heparin?

Answer 10

Activation of antithrombin 3 (bodies own anti clotting molecules)

Question 11

What is the mechanism of warfarin?

Answer 11

Acts of the liver to inhibit the enzyme Vitamin K reductase

Question 12

What should sufferers of a hemorrhagic stroke do if they are on anticoagulants?

Answer 12

Stop anticoagulating

Question 13

What 3 methods can reverse anticoagulation?

Answer 13

Stop anticoagulants
Vitamin K to reverse warfarin
Clotting factors