substance use Flashcards
substance use disorder
pattern of drug use leading to impairment or distress with a cycle of craving and relapse
how do drugs become misused
the activation of brain reward system specifically the dopamine pathway in mesolimbic system and physical dependence (tolerance and withdrawal)
what is the positive reinforcing system of substance disorder
dopamine reward system
what is the negative reinforcing system
physical dependence
where is dopamine reward system located
mesolimbic system
what is the proper name for a pathway where the signal between 2 cells is dopamine
dopaminergic pathway
what does prolonged DA lead to
intense euphoria
what is responsible for the strong craving substance users experience
chronic depletion of intracellular DA
opioids mechanism of action
reduce sensation of pain and causes euphoria
opioid mechanism of misuse
dependence due to activation of opioid receptors in the reward pathway
what is compulsive use behind substance use disorder
activation of DA becomes compulsion and a cycle of craving and relapse
what plays a role in the compulsive use of drugs
- method of consumption
- pharmacological effects
T/F. tolerance is a symptom of dependence
true
what happens with repeat exposure to opioids
there is cellular adaptation and you will require more of the drug to illicit the same effect as before
where will PD tolerance shift the dose response curve
to the right
