Systemic Responsr To Injury Flashcards
1
Q
SIRS definition
A
Temp >/=38(100.4F) or = 36(96.8F) HR >/= 90bpm RR >/= 20 Pco2 =32 mmHg WBC >/= 12000/uL or = 4000/uL or 10% band forms
2 or more of these
2
Q
Septic shock
A
Sepsis + cardiovascular collapse
3
Q
HMGB1 receptors
A
TLR 2,4,9
RAGE
CD24
4
Q
Mitochondrial DNA
A
TLR 9
5
Q
Heat shock proteins
A
TLR 2,4 CD40, 14
6
Q
Hyaluronan
A
TLR2,4 CD44
7
Q
Biglycan
A
TLR 2,4
8
Q
Prolonged immunosuppressed state may be induced by
A
Lesser inflammatory response followed by CARS
9
Q
Severe inflammation may affect ____________ ____________ failure
A
Multiple organ failure
10
Q
Vagal Response
A
Rapidly induce acetylcholine release directed at site of injury ~ curtail inflammatory response
11
Q
Released by Sympathetic ANS
A
Epi and Norepi
12
Q
Release by Parasympathetic ANS
A
Acetylcholine
13
Q
Principal regulator of steroid synthesis
A
ACTH
