T-cell 1: Intro to cell-mediated immunity

Question 1

T-cells: which part of Adaptive immunity?

Answer 1

Cell-mediated

Question 2

T-cell immunity

Answer 2

CD4+ T-cells

• helper t-cells
• help phagocytes kill engulfed pathogens
• help B-cells make antibodies
• help recruit inflammatory cells
• regulate the immune response (t-regulatory cells)

CD8+ T-cells

• cytotoxic t-cells
• kill pathogen-infected (usually viral infected) host cells

Question 3

T-cell receptors

Answer 3

T-cell receptors:

• variable region
• constant region
• stay on T-cells surface membrane

Each T-cell has a unique TCR that will only bind a specific antigen in the context of being presented on an MHC molecule