T1 Flashcards

1
Q

Describe the nature of water.

A
  • Polar molecule due to an unevenly distributed charge.

- Hydrogen end slightly positive and Oxygen end is slightly negative. Hence dipole nature.

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2
Q

What are the 3 main properties of water?

A

1) Solvent properties.
2) Thermal properties.
3) Very cohesive.

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3
Q

Explain the solvent properties of water.

A

Chemicals dissolve easily due to dipole nature. Hence, biochemical reactions occur in cytoplasm.

Polar molecules dissolve easily in water and are therefore hydrophilic.

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4
Q

Explain the thermal properties of water.

A

Water has a very high specific heat capacity; energy required to raise 1g of water by 1 degree is high.

Meaning large amounts of energy is required to break the hydrogen bonds.

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5
Q

What is meant by water being very cohesive and what are the benefits?

A

Cohesion is the attraction between molecules of the same type.

Given that water has a dipole nature, it is very cohesive so this helps water to flow so it’s great for transporting substances.

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6
Q

What is the transport medium?

A

All liquids and particles are transported in one direction due to a difference in pressure called mass flow.

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7
Q

What are some of the dissolved substances contained in the plasma (mainly water)?

A
  • Oxygen, Carbon dioxide
  • Proteins and amino acids
  • Salts
  • Enzymes
  • Hormones
  • Antibodies
  • Urea
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8
Q

Define diffusion.

A

Movement of molecules or ions from a high concentration to a low concentration.

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9
Q

What is an open circulatory system?

A

1) Heart pumps and blood circulates in large open spaces surrounding organs where it then diffuses between the blood and cells.
2) Heart relaxes and the blood is drawn in from the cavities through small valve openings.

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10
Q

Explain how a Closed circulatory system works.

A

1) Blood leaves the heart via arteries then arterioles to capillaries.
2) Exchange (diffusion) happens from capillaries to cells.
3) Then the blood returns to the heart via venules then veins.

Animals with a closed circulatory system tend to be larger in size and more active.

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11
Q

What is the purpose of valves?

A

Prevent blood flowing backwards so all the blood flows in one direction.

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12
Q

Explain how the single circulatory system works.

A

1) Heart pumps deoxygenated blood to the gills.
2) Gaseous Exchange happens; oxygen diffuses in and carbon dioxide out.
3) Blood leaves the gills and circulates the body
4) Blood returns back to the heart.

E.g. A fish

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13
Q

How does a double circulatory system work?

A

1) Right ventricle pumps deoxygenated blood to the lungs.
2) It then returns to the heart where the left ventricle pumps the oxygenated blood.
3) It then circulates the body before returning back to the heart.

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14
Q

What are the advantages of a double circulatory system?

A

1) blood flows through blood vessels which are narrow increasing blood pressure so it’s more efficient.
2) second pressurised pump allows for the oxygenated blood to flow faster around the body allowing for a higher metabolic rate as more nutrients can be rapidly delivered.
3) first pump is slower allowing for a more efficient gaseous exchange.

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15
Q

Explain the different between the left ventricle and the right ventricle?

A

Left ventricle is thicker with more muscular walls as it needs to pump blood around the whole body.

Right ventricle is smaller as it only needs to pump blood to the lungs with a more effective weak pump so gas Exchange is more effective.

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16
Q

Where are the atrioventricular valves?

A

They link the atria and ventricles and stop blood flowing backwards into the atria when the ventricles contract.

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17
Q

Where are the semi-lunar valves?

A

Link the ventricles to the pulmonary arteries and aorta, stopping blood flow back into the heart after the ventricles contract.

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18
Q

What is the basic structure of the heart?

A

It is made out of cardiac muscle and has 4 chambers with a double pump.

Right side receives deoxygenated blood.

Left side receives oxygenated blood.

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19
Q

What is the structure of arteries?

A
  • Narrow lumen
  • Thicker walls
  • More collagen, smooth muscles and elastic fibres
  • No valves
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20
Q

What is the structure of veins?

A
  • Wide lumen
  • Thinner walls
  • Fewer collagen, smooth muscles and elastic fibres
  • Valves
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21
Q

What is the structure of capillaries?

A
  • Smallest of the blood vessels
  • One cell thick
  • Branches like a web
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22
Q

What happens during atrial systole?

A

1) Blood under low pressure flows from left to right atria from pulmonary veins and vena cava.
2) Atria fill opening the atrioventricular valves and then contract allowing blood into ventricles.

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23
Q

What happens in ventricular systole?

A

1) Ventricles contract increasing pressure in the ventricles.
2) It results in the semi-lunar valves opening.
3) Thus, blood flows through the pulmonary arteries and aorta.

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24
Q

What is Cardiac Diastole?

A

Both atria and ventricles relax and the elastic recoil of the relaxing heart reduces the pressure.

Coronary arteries fill during diastole. Low pressure in the atria helps draw blood into the heart from the veins.

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25
Q

Explain the process of atherosclerosis.

A

1) Endothelium with arteries becomes damaged and dysfunctional due to high blood pressure.
2) Inflammatory response occurs and the white blood cells move to the artery wall. Cells accumulate with cholesterol leading to fatty deposits called atheromas.
3) Calcium salts and fibrous tissue build up resulting in hard swelling called plaque. Loss of elasticity and hardens.
4) Plaque results in narrower lumen increasing blood pressure; positive feedback.

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26
Q

How are platelets specialised for their function?

A

Platelets change from flattened discs to spheres with thin projectiles causing them to stick to exposed collagen of the wall.

This forms a temporary platelet plug and also release of substances that activates more platelets.

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27
Q

Explain the process in which blood clotting happens.

A

1) Platelets and damaged tissue release a protein called thromboplastin.
2) Thromboplastin activates an enzyme that catalysed the conversion of the protein prothrombin into thrombin.

Vitamin K and calcium ions must be present.

3) Thrombin catalysed the conversion of soluble protein fibrinogen into the insoluble protein fibrin.
4) This forms a mesh of fibrin that traps more platelets and red blood cells to form a clot.

28
Q

What can the effects of atherosclerosis and blood clots lead to?

A

Heart attacks (myocardial infarction) - if coronary arteries become completely blocked from blood clots.

Coronary heart disease (CHD) - when coronary arteries limit flow to the heart due to atheromas.

Strokes - rapid loss of brain function due to disruption in the blood supply to the brain.

Deep vein thrombosis - blood clot in a vein deep inside the body, usually from prolonged inactivity.

29
Q

What lifestyle factors can increase the risk of cardiovascular disease?

A
  • Diet : high amounts of saturated fats increases atheromas ~> blood clots.
  • Smoking : carbon monoxide binds to haemoglobin reducing oxygen in the blood.
    Nicotine makes platelets sticky.
  • Inactivity : heart is weaker so higher blood pressure.
30
Q

What factors are beyond controlling that increase the chance of CVD?

A
  • Genetics : inherit alleles that make it more likely to have high blood pressure.
  • Age : Plaque builds up slowly over time; increasing the chances of CVD as you get older.
  • Gender : due to hormones, oestrogen in females produces good cholesterol. Men lack this.
31
Q

What is the definition of risk?

A

The probability of occurrence of some unwanted even or outcome.

32
Q

Why might some people overestimate a risk?

A
  • Involuntary (no control)
  • Not natural
  • Dreaded
  • Unfair
  • Negatively portrayed by media
33
Q

Difference between correlation and causation.

A

Correlation is one when one variable affects another variable.

Causation is when one variable is responsible for the change in another variable.

34
Q

Define hypertension.

A

Elevated blood pressure.

35
Q

What’s the purpose of a sphygmomanometer?

A

Measures two readings; systolic pressure, then diastolic pressure.

36
Q

What is oedema?

A

It is when fluid builds up in the tissues and causing swelling.

If blood pressure rises above normal, more fluid may be forced out of the capillaries.

37
Q

Explain what is meant by an energy budget?

A

It is the amount of energy taken in by an organism and the amount of energy used up.

Energy budget = Energy input - Energy output.

38
Q

What is the structure of carbohydrates?

A

They are large complex molecules composed of long chains of monosaccharides.

E.g. Starch.

39
Q

What is the structure of monosaccharides?

A

They are small basic molecules.

They provide a rapid source of energy and are readily absorbed.

Glucose, galactose and fructose contain 6 carbon atoms - hexose sugars.

Hexose sugars - has a ring structure formed by 5 carbons and 1 oxygen atom.

40
Q

What is the structure of disaccharides?

A

The joining of two single sugar units by a condensation reaction releasing a water molecule forming a glycosidic bond.

A hydrogen on one monosaccharides bonds to a hydroxyl on another; releasing water.

Breaking of a disaccharide glycosidic bond is a hydrolysis reaction using water.

41
Q

What are 3 examples of disaccharides.

A

Sucrose - glucose + fructose
(1-2 glycosidic bond)

Maltose - glucose + glucose
(1-4 glycosidic bond)

Lactose - glucose + galactose
(1-4 glycosidic bond)

42
Q

What are polysaccharides?

A

They are long straight or branched chains of sugar units.

Formed when monosaccharides join together.

Starch and glycogen act as an energy storage within cells. They’re compact with low solubility in water.

E.g. Amylopectin and Glycogen.

43
Q

Describe the structure and use of starch.

A

Starch is a mixture of two polysaccharides alpha-glucose (amylose and amylopectin).

It is the main energy storage in plants.

It is insoluble in water so it doesn’t enter the cells by osmosis making it good for storage.

44
Q

What’s the differences between amylose and amylopectin?

A

Amylose - long, unbranched chain of glucose joined together with 1-4 glycosidic bonds. It has a coil structure like a cylinder making it compact; good for storage.

Amylopectin - long, branched chain of glucose that contains 1-4 and 1-6 glycosidic bonds. It has side branches which allow enzymes to break the molecules easily so glucose can be released quickly.

45
Q

Describe the structure and function of glycogen.

A

It is the main energy storage in animals, and is insoluble in water so no osmosis.

Structure is similar to amylopectin; 1-4 and 1-6 glycosidic bonds except it has a lot more side branches so energy can be released quickly.

It is very compact so it’s good for storage.

46
Q

What is cellulose?

A

It is a dietary fibre - non starch polysaccharide.

It has an important function in the movement of material through the digestive tract.

47
Q

Describe the structure of triglycerides.

A

1 molecule of glycerol with 3 fatty acids joined by ester bonds.

3 ester bonds formed in a triglyceride.

Fatty acid tails are made of hydrocarbons (carbon chains with hydrogen branching off).
Tails are hydrophobic and thus are insoluble in water.

Formed in a condensation reaction and broken up by a hydrolysis reaction.

48
Q

What are lipids and their function?

A

It is a general term for fats and oils.

Supply over twice the energy of carbohydrates.

Large amounts of energy within small mass of food.

Organic molecules found in every type of cell.

Insoluble in water.

49
Q

Explain the structure of saturated fats?

A

If the fatty acid chains in a lipid contain the maximum about if hydrogen atoms.

Hydrocarbon chain is long and straight.

No double bonds.

They can be packed closely together.

Strong intermolecular bonds - solid at room temperature.

50
Q

What are the two different types of unsaturated fats and explain the difference.

A

1) Monounsaturated fats have 1 double bond between two of the carbon atoms. Causes a kink.
2) Polyunsaturated fats have more double bonds. Kink prevents them from being compact. So increasing the distance between molecules weakens the intermolecular forces. Thus, a liquid at room temperature.

Add hydrogen to double bonds to be solid.

51
Q

What is cholesterol?

A

It’s a short lipid that is vital for cell membranes.

52
Q

In whom is the BMR higher in?

A
  • Males
  • Heavier people
  • Younger people
  • More active people
53
Q

What is your BMI?

A

Body mass index - method of classifying body weight relative to a persons height.

Body mass (kg) / height * height

54
Q

What is obesity?

A

When your energy input is largely greater than your energy output.

It increases your risk of coronary heart disease and stroke.

It also increases your blood pressure and elevates your blood lipid levels.

55
Q

What is a lipoprotein and what are the two major transport lipoproteins?

A

Insoluble cholesterol combined with proteins to form soluble lipoproteins.

1) Low-density lipoproteins
2) High-density lipoproteins

56
Q

What is a LDL and it’s function?

A

Combination of cholesterol and protein which transports cholesterol to body cells.

Circulates in the blood stream to bind to receptor sites on cell membranes before being taken up.

Excess LDLs overload the receptors resulting in high blood cholesterol levels. It may also be deposited in the arteries forming atheroma.

57
Q

What is a HDL and it’s function?

A

Higher percentage of proteins making it more dense.

Transport cholesterol from the body tissues to the liver to be broken down.

Lowers blood cholesterol and helps remove fatty plaques.

58
Q

What is an apolipoprotein gene cluster?

A

Apolioproteins are the protein components of lipoproteins.

Mostly formed in the liver and intestines.

Important role in stabilising the structure of the lipoprotein. Also, in recognising receptors involved in lipoprotein uptake on the plasma membrane.

59
Q

What are the 3 different types of apolipoproteins?

A

1) APOA - major protein in HDL
2) APOB - major protein in LDL
3) APOE - major component in both and is involved in the removal of cholesterol from the blood to the liver.

3 common alleles - E2, E3, E4.

APOE4 slows the removal or cholesterol increasing chances of CHD.

60
Q

What are unstable radicals?

A

Occurs when an atom has an unpaired electron.

They are highly reactive and can damage many cell components like enzymes and genetic material.

Prevention by consuming vitamins C and E as it provides hydrogen atoms that stabilise the radicals.

61
Q

How can one reduce the risk of CVD?

A
  • Stop smoking
  • Maintaining resting blood pressure
  • Maintaining low cholesterol levels
  • Maintaining abnormal BMI
  • Moderate or no alcohol consumption
62
Q

What’s an ACE inhibitor?

A

It is a antihypertensive drug.

Angiotensin Converting Enzyme Inhibitors - minimise the synthesis of angiotensin 2. It restricts the hormone being produced from angiotensin 1 which is inactive and thus, lowers blood pressure.

Allows more control of blood pressure by causing vasoconstriction.

63
Q

What are Calcium channel blockers?

A

It is an antihypertensive drug that blocks Calcium channels in muscles.

This lowers the blood pressure as muscles are unable to contract.

64
Q

What are diuretics?

A

A drug that removes the body of excess salts and liquids by increasing the volume of urine produced.

Thus, causes a decrease in cardiac output which lowers blood pressure.

65
Q

What is an Anticoagulant and platelet inhibitory drug treatment?

A

It reduces the chance of blood clotting.

Use of aspirin reduces the stickiness of platelets.

Negatives of aspirin; bleeding from gastrointestinal tract.

Substitute is clopidogrel.

66
Q

What is warfarin?

A

It is an anticoagulant drug that affects the production of vitamin K which affects the synthesis of clotting factors.

It has greater benefits than aspirin.