Teratogens Flashcards
1
Q
ACEi
A
Renal damage/dysplasia
2
Q
Alcohol (what are morphological changes?)
A
FAS
- Leading cause of mental retardation
- Limb dislocation
- VSD
- Microcephaly; holoprosencephaly
- INc distance between eyes; short palpebral fissures; long philtrum
- Heart/lung fistula
3
Q
Alkylating Agents
A
Absence of digits, cleft palate, renal agenesis
4
Q
Aminoglycosides
A
CN 8 tox
5
Q
Anticonvulsants
A
Cleft lip/palate
6
Q
Cocaine
A
- Low birth wt
- Placental Abruption
7
Q
Diethlstilbestrol (DES)
A
Vaginal clear cell adenocarcinoma
8
Q
Folate antagonists (MTX, Trimethoprim)
A
Neural tube defects (meningomyelocele)
9
Q
Lithium
A
Ebstein’s anomoly (atrialization of RV)
10
Q
Maternal diabetes
A
- Caudal regression syndrome
- Sirenomyelia (sireno spanish for mermaid)
- Renal dysplasia/aplasia
- Imperforate anus
11
Q
Phenytoin
A
- Cleft lip/palate
- Congenital heart defects
12
Q
Potassium iodide
A
- Goiter/hypothyroidism
- Cretinism
13
Q
Nicotine
A
- Premature delivery
- Low birthweight
- IUGR
- ADHD
14
Q
Tetracyclines
A
Discolored/stained teeth
15
Q
Thalidomide
A
- GI atresia
- Absense or malformation of external ear
- Phocomelia (seal limbs)
