TEST II Flashcards
SECTION 3 (LAST PART)
why is the tissue factor pathway called the extrinsic pathway
Tissue factor is normally found outside the bloodstream
Why admistration of massive amounts of whole blood produce temporary thrombocytopenia
When you transfuse a large volume of whole blood, it dilutes your existing blood volume due to the fact that transfused platelets might be less functional due to storage.
Why is it that asprin containing analgesics may lead to profuse wound bleeding after dental extraction
Aspirin irreversibly inhibits an enzyme called cyclooxygenase. This enzyme plays a vital role in the production of various molecules, including thromboxane A2, a potent inducer of platelet aggregation.
why is it that normal vascular intima prevents bleeding and thrombosis
The intima is a single layer of flat cells called endothelial cells. These cells form a smooth, non-stick surface that minimizes friction between blood cells and the vessel wall while and Endothelial cells produce various substances that actively inhibit platelet activation and aggregation
