the one compartment IV bolus model

Question 1

Assumptions with considering body to be composed of a single compartment

Answer 1

-volume remains constant during the period under study
-any drug within the compartment is distributed evenly & intravenously
-Bolus dose is instantaneous

Question 2

rate of elimination is directly proportional to?

Answer 2

conc. of drug in body

Question 3

what does ke represent?

Answer 3

elimination constant

Question 4

ke=
Equation

Answer 4

CL/ V

Question 5

C=

Answer 5

Coe^-kt

Question 6

Co =

Answer 6

Dose / V

Question 7

Cl=

Answer 7

Dose/ AUCo^ infinity

Question 8

Amount in body mg=

Answer 8

Volume (L) x concentration (mg/L)

Question 9

Initial concentration mg/L =

Answer 9

Dose (mg) / volume (L)

Question 10

Half life =

Answer 10

ln(2) V /CL

Question 11

Concentration at time t

Answer 11

Initial concentration X e^(-CL/V t)

Question 12

One compartment IV bolus dose is when the body is considered to be?

Answer 12

composed of a single compartment with volume (V)
There is an elimination process = clearance

Question 13

Describe the one compartment IV bolus model

Answer 13

We consider the body to be composed of a single compartment with volume (V).
Drug is entered directly into this compartment where it mixes evenly throughout the volume
Drug is removed directly from this compartment through elimination process which may be referred as clearance