Thiazolidinedione Flashcards
1
Q
TZD MOA
A
Activate PPAR-gamma
Increases insulin sensitivity
2
Q
TZD expected change in A1c
A
Low
3
Q
How is TZD administered?
A
Orally
4
Q
TZD ADEs
A
Fluid retention/significant LE edema
HF, increased risk of fx
5
Q
TZD risk of hypoglycemia
A
Low
6
Q
TZD causes weight gain or loss?
A
Gain
7
Q
TZD CV impact
A
Improves some outcomes
Increases risk of HF
8
Q
TZD renal impact
A
May improve albuminuria
9
Q
TZD precautions/CIs
A
HF, bladder cancer
10
Q
TZD drug interactions
A
CYP450
11
Q
TZD cost
A
Low
