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Amgen Interview > Things to know > Flashcards

Things to know Flashcards

1
Q

Aimovig

A

Migraine

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2
Q

Aranesp

A

Anemia from ckd or chemotherapy

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3
Q

Blincyto

A

T-cell Engager for acute lymphoblastic leukemia

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4
Q

Corlanor

A

Reduce risk of hospitalization for worsening heart failure

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5
Q

Enbrel

A

Arthritis

Auto-injector

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6
Q

Epogen

A

Anemia from ckd

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7
Q

Imlygic

A

Melanoma legions

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8
Q

Kyprolis

A

Multiple myeloma

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9
Q

Neulasta

A

Febrile neutropenia

Onpro

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10
Q

Neupogen

A

Febrile neutropenia

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11
Q

Nplate

A

Thrombocytopenia

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12
Q

Parsabiv

A

Secondary hyperparathyroidism from ckd

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13
Q

Prolia

A

Osteoporosis

High revenue, high growth

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14
Q

Repatha

A

1) Reduce risk of cardiac related incidents

2) reduce ldl (too high pricing initially for this indication)

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15
Q

Sensipar

A

1) secondary hyperparathyroidism from ckd

2) hypercalcemia

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16
Q

Vectibix

A

Colorectal cancer

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17
Q

Xgeva

A

1) Skeletal related events from multiple myeloma or bone metastasis from solid tumors
2) hypercalcemia of malignancy

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18
Q

Oprozomib

A

Phase 1

Multiple myeloma

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19
Q

Tezepelumab

A

with AstraZeneca

1) Asthma (phase 3)
2) atopic dermatitis (phase 2)

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20
Q

Enevity

A

Phase 3 with UCB and astellas

Osteoporosis

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21
Q

Omecamtiv

A

Phase 3

Chronic heart failure

22
Q

Kanjinti

A

Biosimilar with Allergan

HER2+ breast or gastric cancer

23
Q

Antibody drug conjugate

A

Cytotoxic cancer drug linked to antibody for targeted treatment

24
Q

Bispecific antibody

A

Antibody with two disease targets

25
Q

BiTE antibody construct

A

Bispecific T cell engager

Link target regions of two antibodies, one for T cell surface protein, and one for tumor cell protein

26
Q

Car T cell

A

Chimeric antigen receptor T cell

Genetically engineered T cells designed to target specific tumor type

27
Q

Fusion protein

A

Combination of two proteins

28
Q

Monoclonal antibody

A

Bioengineered molecules designed to target specific proteins

29
Q

Oncolytic immunotherapy virus

A

Genetically modified viruses which replicate only in tumor cells and cause cell lysis, and produce human signaling proteins to summon immune cells

30
Q

Peptibody

A

Combines activity of peptide with longer duration of activity of an antibody

31
Q

Manufacturing of the future

A

Greater productivity
Smaller footprint which allows expansion to almost anywhere
1/5th cost
Can be built in 2 years
Single use bioreactors + disposable plastic containers
Standardized processes throughout development
Modular/flexible design

32
Q

Values

A 
Be science based
Compete intensely and win
Create value for patients, staff, and stockholders 
Be ethical
Trust and respect each other
Ensure quality
Work in teams
Collaborate, communicate, and be accountable
33
Q

Mission

A

To serve patients

34
Q

Therapeutic areas

A

Bone
Cardiovascular (bayer, sanofi)
Hematology/oncology (j&j, teva, celgene)
Inflammation (abbvie)
Neuroscience (biogen, Pfizer, teva, Novartis)
Nephrology

35
Q

Amg 520

A

Phase 3 with Novartis

Prevention of Alzheimer’s

36
Q

Revenue 2017

A

~$23 B

37
Q

Net income 2017

A

~$2 B

38
Q

SGA

A

~$5B

39
Q

R&D

A

~$3.5B

40
Q

Cost of sales

A

~$4B

41
Q

Operating leverage

A

Contribution margin/net operating income

Q(price - var cost)/(Q(price-var cost)-fixed cost)

42
Q

Effective tax rate

A

11-13% recent quarters

~80% in 2017 due to repatriation tax

43
Q

Income statement - balance sheet

A

Net income feeds into retained earnings

Depreciation flows out of balance sheet from PPE onto income statement as expense

Changes in current A and L on balance sheet are related to rev and expense on income statement

Interest expense appears on income statement, principle of debt sits on balance sheet

44
Q

Income statement to cash flow statement

A

Net income is starting point for cash from operations section

Depreciation from income statement added back in cash flow

45
Q

Balance sheet - cash flow

A

Cap ex add to the PPE on balance sheet and flow through cash from investing on cash flow

Changes in current A and L on balance sheet need to be adjusted on cash flow to reflect actual amount of cash received or spent

Change in principle amount owed on balance sheet is reflected on cash from financing section of cash flow

Cash from ops/investing/financing added to prior period cash on balance statement

46
Q

How 3 statements are linked

A

Net income from income statement flowing to balance sheet and cash flow statement

Depreciation is added back and capex is deducted on cash flow, which determines ppe on balance sheet

Financing activities mostly affect the balance sheet and cash from financing, except for interest which is on income statement

Sum of the last periods closing cash plus cash from ops/financing/investing is closing cash balance on balance sheet

47
Q

Income statement

A

Revenue

Operating expense

Interest expense

Taxes

Earnings per share

48
Q

Balance sheet

A 
Assets
Current
Ppe
Intangible 
Good will
Other

Liabilities
Current
Long-term debt
Long-term deferred tax and tax liabilities

Stockholders equity

49
Q

Cash flow

A

Ops
Investing
Financing

50
Q

Valuation

A

Risk adjusted npv

Market multiples
Comparative valuation
Dcf

51
Q

Todd tushla

A

Notre Dame b.s. biology

Usc mba

52
Q

Product revenue %

A

Enbrel 25%
Neulasta 21%
Aranesp 9%
Prolia 9%

Amgen Interview (1 decks)

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