TNF and Integrin Inhibitors + IFN agonists

Question 1

Entanercept

Answer 1

Enbrel

• Two soluble TNF receptor linked together then bound to the FC region of IgG1
• Act as adeco and binds both TNFa and TNFb
• Usee: RA, psioriatic arthritis
• ADE: increase infection risk

Question 2

Infliximab

Answer 2

Remicade

• Chimeric human+ mouse IgG antibody neutralizes all forms of TNfa
• Used: RA, Chronn’s, and ulcerative colitis
• ADE: Risk of infection, lymphoma and other cancers as well as leukopenia

Question 3

Adalimumab

Answer 3

Humira

• Fully human monoclonal antibody
• Used: Ulcerative colittis, Chronn’s, RA
• ADE- increased risk of infection

Question 4

Certolizumab pegol

Answer 4

Cimza

• Pegylated Fab fragment of humanized monoclonal antibody
• Use: RA and Chronn’s

Question 5

Natilizumab

Answer 5

Tysabri

• Humanized mouse antibody against intergrin alpha4 prevent the WBC from squeezing through blood vessels and into tissue (especially brain)
• Use: Chronns and MS
• ADE: hepatotoxicity, allergic rxn, PML association

Question 6

Vedolizumab

Answer 6

Entyvio

• Humanized mouse antibody that binds to alpha4 beta7intergrin
• Use: Chronns, ulcerative colitis,
• ADE-: Risk of infection, risk vs benefit for PML, hepatoxicity,

Question 7

Peg-interferon-2alpha

Peg-interferon-2beta

Answer 7

Pegasys (same dose for all pts.)
Pegintron (dose is based on weight)
-PEG bound to INF to increase the 1/2
-Use: HCV and some HBV
-Antiviral and INF agonist activity increase immune response
-ADE: Flu like symptoms, Depression and neutropenia

Question 8

Interferon-beta1A

Answer 8

Avonnex

• Glycoprotein
• Use: MS
• ADE: flu like symptoms, depression, seizures, injection site reaction, liver problems

Question 9

Interferon-gamma-1B

Answer 9

Actiummune

• single chain polypeptide
• stimulates the immune system by activating macrophages, enhance MHC, activate effector Tcells
• Use: granulomatoris disease, malignant osteoporosis
• ADE: flu like symptoms

Question 10

Omalizumab

Answer 10

Xolair
-Humanized Anti IgE
-Blocks IgE from binding to FcERi on basophils and mast cells to inhibit the release of histamine and 
Use: allergic asthma 
ADE: anaphylaxis

Question 11

Palivizumab

Answer 11

Synagis

• Humanized antibody
• Binds to the fusion protein of RSV to prevent infection
• Use: prophylaxis in babies with RSV
• ADE: sore throat, runny nose, redness at injection site, V/D