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Oral Biology II COPY > Tooth Development - D'Souza > Flashcards

Tooth Development - D'Souza Flashcards

1
Q

What guides organogenesis?

A

Epithelial-mesenchymal interactions

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2
Q

What are the 4 types of cell communication?

A

1-Autocrine (cell on itself) 2-Paracrine (Cell on another near by) 3-Endocrine (carried by blood stream) 4-Intracrine (acts inside the cell rather than on receptors)

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3
Q

Migration of Neural crest cells to where is important for development of oral tissues?

A

1st arch

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4
Q

Ectomesenchyme (neural crest) is responsible for what parts of the dentition?

A

-Dentin -Bone -Cementum -Periodontal ligament

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5
Q

What thickened band of cells early in development eventually give rise to teeth?

A

Dental lamina

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6
Q

An early bud off (successional dental lamina) of the larger forming tooth bud is likely to be what?

A

Succedaneous tooth (permanent tooth)

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7
Q

What are the 6 stages of Crown development?

A

1-Initiation (induction) 2-Bud stage (proliferation) 3-Cap stage (proliferation, differentiation, morphogenesis) 4-Bell stage (proliferation, differentiation, morphogenesis) 5-Apposition stage (induction and proliferation) 6-Maturation stage

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8
Q

The process whereby one tissue changes the development of surrounding tissues is called what?

A

induction

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9
Q

The inner area of the tooth germ is called what?

A

enamel organ or now it is called the dental organ

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10
Q

the condensed ectomesenchyme oaround the developing cap of the tooth germ is called what?

A

dental papilla

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11
Q

The location of differential genes where expression begins is called what?

A

the enamel knot

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12
Q

What are the four layers of the bell stage? What is the function for each?

A

1-outer enamel epithelium (protects enamel organ) 2-stellate reticulum (star shaped, support enamel production) 3-stratum intermedium (separates layers, supports enamel mineralization) 4-inner enamel epithelium (becomes ameloblasts)

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13
Q

The junction of the outer and internal enamel epithelium is called what?

A

Cervical loop

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14
Q

What stimulates the pre-dental ectoderm to produce Fgf-8?

A

Lef-1

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15
Q

What induces the underlying mesenchyme to express Pax-9 and Msx-1 beneath the thickened dental lamina?

A

Fgf-8

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16
Q

What inhibits Fgf-8?

A

BMP-2 and 4

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17
Q

The dental sac later develops into what?

A

Periodontal tissue

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18
Q

The stage during which organic matrix of enamel and dentin are laid down is called what?

A

Appositional stage

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19
Q

What is the order of reciprocal induction?

A

-Inner Enamel Epithelial cells differentiate into pre-ameloblasts and become polarized -Preameloblasts then include outer dental papilla cells to differentiate into preodontoblasts which turn into odontoblasts

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20
Q

Preameloblasts start producing enamel when they see what, produced by odontoblasts?

A

Predentin

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21
Q

What is formed once the basement membrane in between Ameloblasts and Odontoblasts disintegrates?

A

Dentinoenamel junction (DEJ)

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22
Q

Tomes processes of late secretory ameloblasts form what?

A

Enamel prisms (prismless enamel is formed by early secretory ameloblasts)

23
Q

Enamel matrix secreted by Ameloblasts immediately calcify to ______% of full mineralization

A

25%

24
Q

What are the seven stages of ameloblast life cycle

A

1-Inner enamel epithelial cells 2-Preameloblasts (reverse polarity) 3-Initial secretory ameloblast (prismless enamel) 4-Secretory ameloblast (Tomes process/enamel process) 5-Smooth-ended maturation ameloblast (remove protein/water) 6-Ruffled-ended maturation ameloblast (introduction of inorganic material) 7-Protective ameloblast (enamel cuticle)

25
Q

Once the enamel has fully matured what forms?

A

Reduced enamel epithelium (REE)

26
Q

initial dentin mineralization is in the form of globules and produces what?

A

globular dentin

27
Q

Initial layers of dentin next to the DEJ is called what?

A

Mantle dentin (Perpendicular fibers)

28
Q

Dentin around the pulp is called what?

A

Cirumpulpal dentin (parallel fibers)

29
Q

What is the the connection of inner enamel epithelium and outer enamel epithelium that induces root formation and then disintegrates?

A

Hertwigs Epithelial Root Sheath (HERS)

30
Q

Hertwigs Epithelium Root sheath remnants that persist in the Periodontal ligament are called what?

A

Epithelial rests of Malassez

31
Q

Induction of dental sac cells differentiate into what?

A

Cementoblasts which secrete cementoid which mineralizes into cementum *if cemtoblasts are trapped into lacunae they are cemtocytes

32
Q

Dental sac ectomesenchyme cells differentiate into what?

A

Fibroblasts that secret collagen and form the PDL

33
Q

What signaling molecules start the formation of the dental placodes and thus the dental lamina?

A

SHH Lef1 Msx-1

34
Q

what structure, that is next to the dental lamina, dies to give rise to the labial or lingual sulcus?

A

the vestibular lamina

35
Q

what is the old name for the lamina/bud stage?

A

initiation

36
Q

what is the old name for the cap/early bell stage?

A

morphogenesis

37
Q

what is the old name for the late bell stage?

A

cell terminal differentiation

38
Q

what is the old name for the dentin/enamel/cementum/bone stage?

A

matrix synthesis

39
Q

what structures do we find in the cap stage?

A

enamel organ dental papilla dental follicle

40
Q

at the cap stage, ectomesenchyme cells condense around the developing cap. These become what two things?

A

dental papilla dental sac

41
Q

what 3 things make up the ‘tooth germ’

A

enamel organ dental papilla dental sac

42
Q

what side of the tooth does the sucessional dental lamina form (the dental lamina that will give rise to the succedaneous tooth?

A

lingual side

43
Q

at the advanced cap stage, what is taking over the signalling?

A

the mesenchyme or more specifically the dental papilla

44
Q

what about growth patterns allow cusp formation?

A

differential growth rates cause cusp formation and folding of the tooth.

45
Q

the dental sac gives rise to what?

A

the periodontium/alveolar bone

46
Q

what are some event highlights that happen in the apposition stage after odontoblasts and ameloblasts are differentiated and start functioning?

A

the DEJ forms Odontoblasts retreat from the DEJ leaving processes within predentin Ameloblasts retreat from the DEJ while initially laying down prismless enamel

47
Q

what structure induces the differentiation of preameloblasts into ameloblasts?

A

predentin

48
Q

where does the PDL come from?

A

the dental sac ectomesenchyme cells differentiate into fibroblasts which secrete collagen that become the ligament

49
Q

T/F The roots are fully formed at eruption.

A

False

50
Q

According to D’Souza, what are some important molecules in embryonic development?

A

TGF-Beta (BMP in this fam) FGF SHH Wnt

51
Q

What is the field theory of tooth development?

A

says that the neural crest cells come down and then get influenced by factors that tell them what tooth to become

52
Q

what is the clone theory of tooth development?

A

the cells come from the neural crest and they are partially preprogramed with a particular tooth identity

53
Q

What tissue induces early tooth formation? the epithelium or the mesenchyme?

A

first the epithelium has inductive power, then later the dental papilla mesenchyme has inductive power.

Oral Biology II COPY (15 decks)

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